Results 121 to 130 of about 1,400,025 (294)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Arabic script based character segmentation: a review

open access: yes, 2013
Segmentation based Arabic script based languages character recognition has been a popular field of research for many years. The challenging nature of Arabic script recognition has attracted the attention of researchers from both industry and academic ...
K Hayat (13328220)   +4 more
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

A Modular Privacy-Preserving Framework for Travel Document Segmentation and Information Extraction Using Synthetic Data

open access: yesCybernetics and Information Technologies
Automated travel document recognition is a key technology for digital identity verification. However, robust extraction of structured information from images captured in unconstrained conditions remains challenging due to perspective distortion ...
Nakov Plamen   +4 more
doaj   +1 more source

UnifiedCut: A Simple and Efficient Neural Model for Thai, Burmese and Khmer Word Segmentation

open access: yesApplied Sciences
Word segmentation is a critical task in natural language processing for southeast Asian Abugida languages, including Thai, Burmese, and Khmer. Existing approaches demonstrate that models using fixed-length windowed context inputs can achieve high ...
Yonghua Wen   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The Impact of Color Cues on Word Segmentation by L2 Chinese Readers: Evidence from Eye Movements

open access: yesBehavioral Sciences
Chinese lacks explicit word boundary markers, creating frequent temporary segmental ambiguities where character sequences permit multiple plausible lexical analyses. Skilled native (L1) Chinese readers resolve these ambiguities efficiently.
Lin Li   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

A semi-supervised map segmentation of brain tissues [PDF]

open access: yes, 2004
This paper presents a method for semi-supervised MAP (maximum a-posterior probability) segmentation of brain tissues where labelled data are available for either all types of tissues or only a few types of tissues possibly at different levels of quality.
de Silva, C., Li, W., Attikiouzel, Y.
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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