Results 121 to 130 of about 3,459,091 (319)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Evaluation of structural characteristic identification based on the residual load capacity of RCT girder bridge using new sensing technique [PDF]
, 2019 Recent years, domestic bridges have attract ed attention for maintenance. Inspection by proximity visual inspection is the mainstream as one of the present maintenance management methods.
豊福, 晋ノ介 +5 more
core
MoleculesGeum japonicum Thunb. var. Chinese F. Bolle, a traditional Miao medicine with significant clinical potential, is rich in polysaccharides. Despite its importance, there is a scarcity of research on the structure and activities of these polysaccharides. In
Xuan Chen +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Characteristic function approach to the sum of stochastic variables
This paper puts forward a technique based on the characteristic function to tackle the problem of the sum of stochastic variables. We consider independent processes whose reduced variables are identically distributed, including those that violate the ...
Gleria, Iram +3 more
core
"Empirical characteristic function approach to goodness-of-fit tests for the Cauchy distribution with parameters estimated by MLE or EISE" [PDF]
We consider goodness-of-fit tests of Cauchy distribution based on weighted integrals of the squared distance of the difference between the empirical characteristic function of the standardized data and the characteristic function of the standard Cauchy ...
Akimichi Takemura, Muneya Matsui
core
Tropical Medicine and Infectious DiseaseThe different strains of SARS-CoV-2 were detected and labeled in 2021. Each strain differs in both clinical symptoms and severity. Previous studies found different clinical symptoms and treatment outcomes between outbreak waves; however, data in ...
Kitchawan Hengkrawit +3 more
doaj +1 more source
TRUST IN MONO-ETHNIC AND MIXED-ETHNIC ASSOCIATIONS IN PENANG [PDF]
Kajian Malaysia, 2007 Investigation into trust has become a topical issue in current socialscience research. This is, in large part, a result of a perception that trust in institutions has declined markedly in the past two decades.
James K. Campbell, Yen Siew Hwa
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source