Results 31 to 40 of about 600,704 (244)

Absolutely continuous spectrum for one-dimensional Schr\"odinger operators with slowly decaying potentials: some optimal results

, 1997
The absolutely continuous spectrum of one-dimensional Schr\"odinger operators is proved to be stable under perturbation by potentials satisfying mild decay conditions.
Christ, Michael, Kiselev, Alexander
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

An exact formula for general spectral correlation function of random Hermitian matrices

, 2003
We have found an exact formula expressing a general correlation function containing both products and ratios of characteristic polynomials of random Hermitian matrices. The answer is given in the form of a determinant.
Akemann G, Andreev A V, Bleher P, Brezin E, Damgaard P H, Deift P, Deift P, Deift P, Deift P, Deift P, Efetov K B, Eugene Strahov, Fokas A S, Fokas A S, Forrester P J, Fyodorov Y V, Fyodorov Y V, Hackenbroich G, Keating J P, Kharchev S, Mehta M L, Mehta M L, Morozov A, Pastur L, Sagan B, Strahov E, Strahov E, Szegö G, Wilke T, Yan V Fyodorov   +29 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Equivariant Poincar\'e series of filtrations and topology

, 2012
Earlier, for an action of a finite group $G$ on a germ of an analytic variety, an equivariant $G$-Poincar\'e series of a multi-index filtration in the ring of germs of functions on the variety was defined as an element of the Grothendieck ring of $G ...
A. Campillo, A. Campillo, A. Campillo, A. Campillo, A. Campillo, Antonio Campillo, C. T. C. Wall, F. Delgado, Félix Delgado, M. Yamamoto, S. D. Cutkosky, Sabir M. Gusein-Zade   +11 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Discovering the manifold facets of a square integrable representation: from coherent states to open systems

, 2018
Group representations play a central role in theoretical physics. In particular, in quantum mechanics unitary --- or, in general, projective unitary --- representations implement the action of an abstract symmetry group on physical states and observables.
Aniello, Paolo
core   +1 more source