Results 101 to 110 of about 1,124,395 (308)

PSYCHOLOGICAL CHARACTERISTICS OF ADOLESCENT PERIOD

This article talks about the psychology of adolescents of the period and the psychological changes that occur in adolescents and their impact on their development.
M.M. Gadayeva, Nazarova Maftuna Anvarovna   +1 more
openaire   +1 more source

Block bootstrap for periodic characteristics of periodically correlated time series [PDF]

Journal of Nonparametric Statistics, 2017
This research is dedicated to the study of periodic characteristics of periodically correlated time series such as seasonal means, seasonal variances and autocovariance functions. Two bootstrap methods are used: the extension of the usual Moving Block Bootstrap (EMBB) and the Generalized Seasonal Block Bootstrap (GSBB). The first approach is proposed,
openaire   +3 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

How characteristic is the species characteristic selection scale?

, 2019
Aim: The importance of framing investigations of organism–environment relationships to interpret patterns at relevant spatial scales is increasingly recognized. However, most research related to environmental relationships is single‐scaled, implicitly or
Fontaine, Joseph J., Erica F. Stuber, Joseph J. Fontaine, Stuber, Erica F.   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The relationship between drought and El Nino over Botswana [PDF]

, 2001
Numerous studies have shown that drought occurs in Botswana in association with most Pacific ENSO episodes. Using composite analysis, an attempt is made to identify characteristic differences between those episodes during which drought occurs and those ...
Cai, W, Carsten Eden, Beven, K., Baquero Bernal, A., Josey, S.A., Stott, PA, Viviand, J., de Noblet-Ducoudré, Nathalie, N., Stott, P. A., Gregory, J. M., Timbal, B., Tapio Schneider, Bauer, P., Schulz, K., Donlon C, Stott, P., Gallego Puyol, David, Colman, R., Hilmer, Michael, Dickinson, Robert E., Jürgen Willebrand, Biondi, Franco, Sarah C. B. Raper, Raisanen, J, Stephenson, David B., Mcnally, T., R. A. Wood, Dietmar Dommenget, Stouffer, R. J., Marshall, Gareth J., Tett, S. F. B., Joseph McConnell, C. M. Goodess, Chandler, R.E., Maarten H. P. Ambaum, R. B. Thorpe, Jung, Thomas, Collins, M., Gordon, HB, Holben Brent N., Hegerl, G., William M. Connolley, Schnur, Reiner, Ferreira, David, Willebrand, Jürgen, Gillett, N., Reichert, B.K., Gregory, Jonathan M., Gentemann C, Henderson-Sellers, A, S. J. Watkins, Xie, Shang-Ping, Eden, C., Bonfils, Celine, Grist, J.P., Zhang, H, Palmer, Tim, Stocker, Thomas F., Hernández Martín, Emiliano, Jarvis, Andrew J., Legutke, S., R. J. Stouffer, Paul Valdes, Zeng, Xubin, Mojib Latif, Shi, SY, Melice, JL., Thorncroft, Chris, Cayan, D.R., Murray M, Nightingale T, Jones, Chris D., Fujiwara, Masatomo, Schnur, R. ; https://orcid.org/, Gulev, Sergej, Weaver, A. J., Tanimoto, Youichi, Osborn, Timothy J., Gershunov, A., Power, S., Slingo, A., Connolley, William M., Hoskins, Brian J., Watkins, S. J., Ruprecht, Eberhard, Johnson, H, Hall, A., González Rouco, Jesús Fidel, Barton I, Knutti, Reto, Collins, M, N. A. Rayner, Takemura Toshihiko, Takeuchi, Kensuke, Palutikof, Jean P., Kinne Stefan, Myneni, Ranga B., Gimeno, Luis, J. M. Gregory, Isaac M. Held, Jonathan M. Gregory, Raper, S. C. B., Collins, Matthew, Liu, W. Timothy, Marshall, John, Hodges, Kevin Ivan, Wheater, H., Berger, André, Helen Johnson, Rayner, N. A., Briffa, K. R., Kumar, P, Kelly, G., Jason Goodman, H. Annamalai, Goodman, J, Baquero-Bernal, A., Allen, MR, Leposo, D., Watanabe, Tomowo, Thorpe, R. B., Latif, M., Dommenget, Dietmar, J. P. Palutikof, Ringer, M. A., Lirola, S., Dubovik Oleg, Saenko, O. A., William W. Hsieh, T. Holt, P. A. Stott, Allen, M., Alex Hall, Thomas Jung, Allen, M. R., Schott, Friedrich, Baines, PG, Jiménez, J. L., Soegaard, H., Nakajima Teruyuki, Chevallier, F., Jakob, C., Allen, Myles, Hashizume, Hiroshi, Eden, Carsten, García Herrera, Ricardo Francisco, Briffa, Keith R., Harangozo, Stephen A., Munnich, M., Eby, M., Coron, A., Dong, Jiarui, Shiotani, Masato, Bate, S., Buermann, Wolfgang, Braconnot, Pascale, T. C. Johns, Friedrich A. Schott, McCreary, Julian P., Schmittner, Andreas, Allan, Richard Philip, Osborn, T. J., Ambaum, Maarten H. P., Hilmer, M., Reichert, Bernhard K., Julian P. McCreary, Goodess, C. M., Brian J. Hoskins, Qian, WH, Yan, Z., Edward Hanna, Frankignoul, Claude, Kawamoto Kazuaki, Stephen A. Harangozo, Duan, J., Spall, Steven A., Hsieh, William W., Selten, F.M., Cox, Peter M., Valero Rodríguez, Francisco, Reichert, B. K., Nakajima Takashi Y., McWilliams, J., Marshall, J, Gillett, N. P., Schweingruber, F. H., Sietse Los, Hegerl, GC, Latif, Mojib, Kattenberg, A., Stouffer, Ronald J., Martin Visbeck, Haarsma, R.J., Raper, Sarah C. B., Gillett, NP, Annamalai, H., S. C. B. Raper, Ribera Rodríguez, Pedro, Oerlemans, J., Schneider, Tapio, Quesada, Vicente, Ward B, Minnett P, Stevens, B. ; https://orcid.org/, Tett, Simon F. B., Wood, R. A., Visbeck, Martin, Reichert, B., Quan, LS, Schnur, R, Joussaume, Sylvie, Palutikof, J. P., Chen, J, Nicholson, S.E., Holt, T., Ronald J. Stouffer, Isham, V., Neelin, J., Trigo, Ricardo M., Mitchell, J. F. B., McGuffie, K, Held, Isaac M., Shang-Ping Xie, Hegerl, G. C., Bengtsson, Lennart, Dommenget, D., Drijfhout, S.S., John Marshall, J. F. B. Mitchell, Vellinga, M., Schweingruber, Fritz H., Bengtsson, L., Johns, T. C.   +232 more
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Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Fortress Salopia: Exploring Shropshire's Military History from the Prehistoric Period to the Twentieth Century

, 2020
Fortress Salopia is the culmination of contributions from heritage and historic professionals, practising archaeologists and academic historians that explores the unique military past of the county of Shropshire from the prehistoric period to the 20th ...
Jenkins, Tim, Abbiss, Rachael
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source