Results 111 to 120 of about 1,124,395 (308)

Scheduling trend analysis of river water quality indexes in Sichuan Province

工程科学与技术, 2009
:In order to predominate comprehensively the abidance situation of water quality indexes of 12 representative inspection stations of main river in Sichuan Province, and to study the scheduling trend characteristic of water qualities, the article analyzed
Liao Jie
doaj  

The Value of Carcass Characteristic EPDs in Bred Heifer Price

This study used hedonic modeling to assess the marginal implicit value of bred heifer characteristics and of carcass characteristic expected progeny differences of bred heifer calves. Using data for 692 pens of Show-Me Replacement Heifers Inc.
Patterson, David J., Randle, Richard, Dhuyvetter, Kevin C., Parcell, Joseph L.   +3 more
core  

Impact of earthquakes on agriculture during the Roman–Byzantine period from pollen records of the Dead Sea laminated sediment

, 2010
The Dead Sea region holds the archives of a complex relationship between an ever-changing nature and ancient civilisations. Regional pollen diagrams show a Roman–Byzantine period standing out in the recent millennia by its wetter climate that allowed ...
Marco, S, Miller, CS, Suzanne A.G. Leroy, Bookman, Revital, Miller, Charlotte S., Shmuel Marco, Charlotte S. Miller, Leroy, Susanne A., Revital Bookman, Leroy, SAG, Bookman, R, Marco, Shmuel   +11 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Overview Chapter 1: Fertility in Europe [PDF]

Early in the 21st century, three-quarters of Europe’s population lived in countries with fertility considerably below replacement. This general conclusion is arrived at irrespective of whether period or cohort fertility measures are used.
Tomas Sobotka, Tomas Frejka
core  

The characteristic of snow cover in Łódź in the period 1950-1989 [PDF]

, 1999
Opracowanie zawiera charakterystykę występowania pokrywy śnieinej w Łodzi. Analizę oparto na 40-letnim materiale pomiarowym pokrywy śnieżnej ze stacji meteorologicznej Łódź-Lublinek.
Niedźwiecki, Mirosław
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source