Results 111 to 120 of about 18,304,067 (333)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

Complexifiable characteristic classes [PDF]

open access: yesJournal of Homotopy and Related Structures, 2014
We examine the topological characteristic cohomology classes of complexified vector bundles. In particular, all the classes coming from the real vector bundles underlying the complexification are determined.
openaire   +4 more sources

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Do State Economics or Individual Characteristics Determine Whether Older Men Work? [PDF]

open access: yes
The difference in labor force participation rates of men aged 55-64 across the United States is astounding. For example, West Virginia has a participation rate below 60 percent, while South Dakota has a participation rate approaching 90 percent (see ...
Alicia H. Munnell   +3 more
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

The Characteristics of (Normal) Pulsars [PDF]

open access: yes, 2002
Pulsars have now been studied for 34 years. We know of the existence of some 1500 objects at radio frequencies. Many of the characteristics of pulsars such as pulsar period, period derivative, spectrum, polarization, etc., have been catalogued for many ...
Wielebinski, Richard
core   +2 more sources

Study on Xiao Longyou's Medical Humanities Thought of "Sincere Heart and Earnest Intention"

open access: yesYixue yu zhexue
By delving into the medical humanistic thoughts of Xiao Longyou, this paper reveals that the core concept of his philosophy is "sincere heart and earnest intentions".
Xiayu XU, Ling HUANG
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy