Results 151 to 160 of about 5,929,433 (269)

Depression, anxiety symptoms, and association with household characteristics in adolescent boys and girls from Matiari District, Pakistan: A community-based cross-sectional study. [PDF]

PLoS One
Perquier F, Campisi SC, Zasowski C, Tombeau Cost K, Wasan Y, Soofi SB, Husain M, Korczak D, Monga S, Szatmari P, Bhutta ZA.   +10 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Incidence, Risk Factors, Management, and Nonunion Rates of Pediatric Scaphoid Fractures: A National Database Study. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Zehner KM, Sanchez JG, Smith-Voudouris J, Colen DL, Halim A, Grauer JN.   +5 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Impact of platelet characteristics on post-transfusion count response in critically ill children on Extracorporeal Membrane Oxygenation: A secondary analysis of the ECSTATIC trial. [PDF]

Transfusion
Karam O, Barney BJ, Coles G, Choudhury TA, Furlong-Dillard J, Ozment C, Bain J, Niebler RA, Chegondi M, Schiller O, Joashi U, Paden M, Nellis ME, ECSTATIC collaborators, Blood Net and PediECMO, subgroups of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI).   +15 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A detailed dataset of motor insurance policies with coverage-specific financial information. [PDF]

Data Brief
Espinosa P, Lledó J, Atance D.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Multimodal assessments of therapist characteristics are largely unrelated to patient outcomes: A preregistered analysis. [PDF]

Clin Psychol Sci
Goldberg SB, Baldwin SA, Flynn AWP, Babins-Wagner R, Caperton DD, Williams CY, Hamm EH, Lam SU, Cozart JK, Deole G, Solomonov N, Kopta SM, Anderson T, Wampold BE, Owen J.   +14 more
europepmc   +1 more source