Results 141 to 150 of about 11,443,820 (318)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Psychometric characteristics of Carver and White’s BIS/BAS scales in Dutch adolescents and their mothers

, 2011
The psychometric characteristics of Carver and White's (1994) BIS/BAS scales were examined in 2 groups of Dutch adolescents (497 early adolescents and 237 middle adolescents, M Age = 13.0 years and 16.4 years, respectively) and their middle-aged mothers (
Meeus, W.H.J., Wim H. J. Meeus, Loes Keijsers, Yu, R., Susan J. T. Branje, Keijsers, L., Branje, S.J.T., Rongqin Yu   +7 more
core   +1 more source

Predicting energy prices and renewable energy adoption through an optimized tree-based learning framework with explainable artificial intelligence

Scientific Reports
This research offers a comprehensive analysis of global energy consumption, focusing on predicting two key metrics: the Energy Price Index and the Renewable Energy Share. The study employs advanced Machine Learning (ML) regression techniques, all further
Tao Tang
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conference Report Education Research Days (2018) [PDF]

, 2019
De 48e editie van de Onderwijs Research Dagen (ORD) werd onder toezicht van de Vereniging voor Onderwijs Research (VOR) afgelopen jaar op 13, 14 en 15 juni in Nijmegen georganiseerd door de Radboud Universiteit, het Radboud UMC en de Hogeschool van ...
Leerstoel Branje, Groen, A, Daas, S.R., van Berlo, L.C.J., Kok, M., Wellner, Heleen, van Meegen, M.M.E., Kesselaar, C.P., Nak, J, Griffioen, D.M.E., Adolescent development: Characteristics and determinants   +10 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Samenwerking tussen professionals in de specialistische hulp en informele mentoren binnen de JIM-aanpak: Het JIM-project fase 2 over trajecten bij Youké waarin met de JIM-aanpak wordt gewerkt. Zeist: Youké [PDF]

, 2020
Leerstoel Branje, Wijsbroek, S.A.M., Sekreve, A.C.V., Branje, S.J.T., Adolescent development: Characteristics and determinants   +4 more
core  

Ignition Characteristics in D-T Helical Reactors

, 1994
"Ignition characteristics in D-T helical reactors of various sizes are studied with the operation path method on the bar{P}_ht tau_E^2-T plane and the POPCON method.
"Mitarai, O., Sudo, S."
core