Results 71 to 80 of about 87,063 (285)

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

Management of hindfoot and ankle in Charcot arthropathy

EFORT Open Reviews
Charcot neuroarthropathy is the most severe complication of the diabetic foot. Its diagnosis is difficult and often overlooked, delaying management, with sometimes disastrous consequences.
Nicolas Cellier
doaj   +1 more source

Adjunctive lateral ankle stabilization in midfoot Charcot reconstruction for ankle joint preservation

Foot & Ankle Surgery: Techniques, Reports & Cases, 2021
Ankle Charcot deformity can occur after midfoot Charcot reconstruction, especially when patients present with hindfoot varus or pre-existing ankle instability.
Nicole K. Cates, DPM, AACFAS, Deepal H. Dalal, DPM, MS, Jacob Wynes, DPM, MS, FACFAS   +2 more
doaj   +1 more source

Biallelic mutations in valyl-tRNA synthetase gene VARS are associated with a progressive neurodevelopmental epileptic encephalopathy. [PDF]

, 2019
Aminoacyl-tRNA synthetases (ARSs) function to transfer amino acids to cognate tRNA molecules, which are required for protein translation. To date, biallelic mutations in 31 ARS genes are known to cause recessive, early-onset severe multi-organ diseases ...
Accogli, Andrea, Ben-Omran, Tawfeg, Bernard, Geneviève, Chowdhury, Shimul, Crawford, John R, Dimmock, David, Friedman, Jennifer, Gleeson, Joseph G, Guerrero, Kether, Hildreth, Amber, Issa, Mahmoud Y, James, Kiely N, Kingsmore, Stephen F, Koehler, Alanna E, Lo, Wing-Sze, Mendes, Marisa I, Musaev, Damir, Nahas, Shareef, Omar, Tarek EI, Salomons, Gajja S, Smith, Desiree E, Stanley, Valentina, Tran, Luan T, Wang, Rengang, Wigby, Kristen, Wright, Meredith S, Xu, Zhiwen, Zaki, Maha S, Zhai, Liting   +28 more
core   +2 more sources

Intraepidermal nerve fibre density as biomarker in Charcot–Marie–Tooth disease type 1A

Brain Communications, 2020
Charcot–Marie–Tooth disease type 1A, caused by a duplication of the gene peripheral myelin protein 22 kDa, is the most frequent subtype of hereditary peripheral neuropathy with an estimated prevalence of 1:5000.
B. Hartmannsberger, K. Doppler, J. Stauber, B. Schlotter‐Weigel, P. Young, M. Sereda, C. Sommer   +6 more
semanticscholar   +1 more source

Unveiling CLC as a Central Regulator of Allergic Rhinitis via the CLC‐CCL26/POSTN Axis: An Integrated Bioinformatics and Experimental Study

Flavour and Fragrance Journal, EarlyView.
We unveil that CLC orchestrates the dual role of eosinophil recruitment via CCL26 and tissue remodelling via POSTN in allergic rhinitis, identifying it as a potential therapeutic target. ABSTRACT Allergic rhinitis (AR) is a chronic airway inflammation driven by a type 2 immune response, yet the molecular mechanisms underlying its persistence and tissue
Fanyu Yuan, Yuhan Dong, Zishuo Guo, Xiaodong Zhao, Jian Liu, Fangyuan Zhu, Shengjie Ge, Chengcheng Liu, Shuai Xu, Ming Xia   +9 more
wiley   +1 more source

Hemoglobin A1C in Charcot: Can It Predict a BKA?

Foot & Ankle Orthopaedics, 2022
Category: Diabetes; Ankle; Trauma; Other Introduction/Purpose: Charcot Foot is a serious and potentially limb-threatening complication of longstanding diabetes, peripheral neuropathy, and trauma.
Brandon J. Martinazzi BS, Kristen Manto PhD, Vincenzo Bonaddio MD, Gregory Kirchner, Hannah Nam, Michael C. Aynardi MD   +5 more
doaj   +1 more source

Impact of Obesity on the Structured Histopathology of Chronic Rhinosinusitis Patients

The Laryngoscope, EarlyView.
ABSTRACT Objectives Obesity is an established risk factor for asthma, which shares common inflammatory pathways with chronic rhinosinusitis (CRS). However, the link between obesity and CRS remains poorly understood. By identifying trends in the structured histopathology (SHP) of obese patients with CRS, we aim to better understand how changes in the ...
Daniel X. Ma, Sushanth Neerumalla, Ali Baird, Russell A. Whitehead, Peter Filip, Bobby A. Tajudeen, Pete S. Batra, Peter Papagiannopoulos   +7 more
wiley   +1 more source

Descripción del gran ataque histérico.

Revista de la Asociación Española de Neuropsiquiatría, 1981
Los autores reconocen dos especies de histero-epilepsia: la histero-epilepsia de crisis distintas, en la que los síntomas de histerismo y de epilepsia se manifiestan separadamente en crisis que no se confunden nunca, y son unas veces ataques de ...
JM Charcot
doaj  

Effect of Diabetes Mellitus, Peripheral Neuropathy, or Charcot Arthropathy on Workers Compensation Claims

Foot & Ankle Orthopaedics, 2016
Category: Diabetes Introduction/Purpose: Charcot neuroarthropathy is a complication of peripheral neuropathy commonly resulting from diabetes mellitus. The actual trigger for a Charcot neuroarthropathy episode is unknown.
J. Speight Grimes MD, Jefferson J. Murphree MD   +1 more
doaj   +1 more source