Results 41 to 50 of about 101,291 (290)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

An 8.72 µW Low-Noise and Wide Bandwidth FEE Design for High-Throughput Pixel-Strip (PS) Sensors

Sensors, 2021
The front-end electronics (FEE) of the Compact Muon Solenoid (CMS) is needed very low power consumption and higher readout bandwidth to match the low power requirement of its Short Strip application-specific integrated circuits (ASIC) (SSA) and to handle
Folla Kamdem Jérôme, Wembe Tafo Evariste, Essimbi Zobo Bernard, Maria Liz Crespo, Andres Cicuttin, Mamun Bin Ibne Reaz, Mohammad Arif Sobhan Bhuiyan   +6 more
doaj   +1 more source

Novel Charge Sensitive Amplifier Design Methodology suitable for Large Detector Capacitance Applications [PDF]

, 2009
Current mode charge sensitive amplifier (CSA) topology and related methodology for use as pre-amplification block in radiation detection read out front end IC systems is proposed1. It is based on the use of a suitably configured current conveyor topology
Gerard Sarrabayrouse b,c and, Laurent Bary b,c, Stylianos Siskos a,, Thomas Noulis a,   +3 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Simulation study on time resolution optimization of silicon drift detector

He jishu, 2021
BackgroundThe silicon drift detector (SDD) has been widely used in space exploration in recent years. The SDD has outstanding energy resolution, but its time resolution is not very satisfactory.
YU Nian, XU Yupeng, CAI Yanke, ZHU Yuxuan, ZHAO Xiaofan, CHEN Can   +5 more
doaj   +1 more source

A new generation photodetector for astroparticle physics: the VSiPMT [PDF]

, 2014
The VSiPMT (Vacuum Silicon PhotoMultiplier Tube) is an innovative design we proposed for a revolutionary photon detector. The main idea is to replace the classical dynode chain of a PMT with a SiPM (G-APD), the latter acting as an electron detector and ...
BARBARINO, GIANCARLO, BARBATO, FELICIA CARLA TIZIANA, CAMPAJOLA, LUIGI, Canfora, F., de Asmundis, R., DE ROSA, GIANFRANCA, DI CAPUA, FRANCESCO, FIORILLO, GIULIANA, Migliozzi, P., Mollo, C. M., Rossi, B., VIVOLO, DANIELE   +11 more
core   +2 more sources

Advancing Research on Biomaterials and Biological Materials with Scanning Electron Microscopy under Environmental and Low Vacuum Conditions

Advanced Engineering Materials, EarlyView.
Herein, environmental scanning electron microscopy (ESEM) is discussed as a powerful extension of conventional SEM for life sciences. By combining high‐resolution imaging with variable pressure and humidity, ESEM allows the analysis of untreated biological materials, supports in situ monitoring of hydration‐driven changes, and advances the functional ...
Jendrian Riedel, Lea Dierker, Antoine Eyram Kwame, Kim Nora Wagner, Jonas J. Unterholzner, Jan‐Henning Dirks, Dorothea Brüggemann   +6 more
wiley   +1 more source

LNSTRIP read-out ASIC for the X-ray strip detectors [PDF]

International Journal of Electronics and Telecommunications
The X-ray imaging systems dedicated for X-ray spectroscopy, based on a semiconductor strip sensors have been recently an important research topic. The most important research objective is working towards improvement of the spectroscopic and position ...
Weronika Zubrzycka-Singh
doaj   +1 more source

Radio-frequency Bloch-transistor electrometer

, 2000
A quantum-limited electrometer based on charge modulation of the Josephson supercurrent in the Bloch transistor inserted into a superconducting ring is proposed.
A. B. Zorin, A. B. Zorin, A. B. Zorin, A. B. Zorin, A. B. Zorin, A. N. Korotkov, A. Shnirman, C. M. Caves, D. V. Averin, D. V. Averin, H. Heffner, H. Takahashi, J. Weber, K. K. Likharev, K. K. Likharev, K. K. Likharev, K. K. Likharev, M. Mück, M. T. Tuominen, M.-O. André, P. K. Hansma, R. F. Voss, R. J. Schoelkopf, S. V. Lotkhov, V. B. Braginsky, V. I. Shnyrkov, V. V. Danilov, V. V. Danilov, V. V. Danilov, V. V. Danilov, Y. Nakamura, Yu. Makhlin, Yu. Makhlin   +32 more
core   +1 more source