Results 31 to 40 of about 2,706,632 (222)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Comprehensive Noise Modeling of Piezoelectric Charge Accelerometer with Signal Conditioning Circuit

Micromachines
This paper reports on noise modeling of a piezoelectric charge accelerometer with a signal conditioning circuit. The charge output is converted into voltage and amplified using a JFET operational amplifier that has high input resistance and low noise ...
Ghulam Ali, Faisal Mohd-Yasin
doaj   +1 more source

Analog CMOS Readout Channel for Time and Amplitude Measurements With Radiation Sensitivity Analysis for Gain-Boosting Amplifiers

IEEE Access, 2021
The front-end readout channel consists of a charge sensitive amplifier (CSA) and two different unipolar-shaping circuits to generate pulses suitable for time and energy measurement.
T. Sanchez-Rodriguez, J. A. Gomez-Galan, F. Marquez, M. Sanchez-Raya, J. Hinojo, F. Munoz   +5 more
doaj   +1 more source

An efficient design of 45-nm CMOS low-noise charge sensitive amplifier for wireless receivers [PDF]

, 2022
Amplifiers are widely used in signal receiving circuits, such as antennas, medical imaging, wireless devices and many other applications. However, one of the most challenging problems when building an amplifier circuit is the noise, since it affects the ...
Almalkawi, Islam T., Al-Karaki, Jamal N., Awni Itradat, Islam T. Almalkawi, Ashraf H. Al-Bqerat, Jamal N. Al-Karaki, Itradat, Awni, Al-Bqerat, Ashraf H.   +7 more
core   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Circuit design of VLSI for microelectronic coordinate-sensitive detector for material element analysis [PDF]

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2012
There has been designed, manufactured and tested a VLSI providing as a part of the microelectronic coordinate-sensitive detector the simultaneous elemental analysis of all the principles of the substance.
Sidorenko V. P., Verbitskii V. G., Prokofiev Yu. V.   +2 more
doaj   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Charge-Sensitive Poly-Silicon TFT Amplifiers for a-Si:H Pixel Particle Detectors [PDF]

MRS Proceedings, 1992
ABSTRACTPrototype charge-sensitive poly-Si TFT amplifiers have been made for the amplification of signals (from an a-Si:H pixel diode used as an ionizing particle detector). They consist of a charge-sensitive gain stage, a voltage gain stage and a source follower output stage. The gain-bandwidth product of the amplifier is ∼ 300 MHz. When the amplifier
Cho, G., Perez-Mendez, V., Mack, M., Lewis, A.   +3 more
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

An 8.72 µW Low-Noise and Wide Bandwidth FEE Design for High-Throughput Pixel-Strip (PS) Sensors

Sensors, 2021
The front-end electronics (FEE) of the Compact Muon Solenoid (CMS) is needed very low power consumption and higher readout bandwidth to match the low power requirement of its Short Strip application-specific integrated circuits (ASIC) (SSA) and to handle
Folla Kamdem Jérôme, Wembe Tafo Evariste, Essimbi Zobo Bernard, Maria Liz Crespo, Andres Cicuttin, Mamun Bin Ibne Reaz, Mohammad Arif Sobhan Bhuiyan   +6 more
doaj   +1 more source