Results 41 to 50 of about 152,917 (265)
Prospects of searches for long-lived charged particles with MoEDAL
We study the prospects of searches for exotic long-lived particles with the MoEDAL detector at the LHC, assuming the integrated luminosity of 30 fb$$^{-1}$$ -1 that is expected at the end of Run 3.
B. S. Acharya +9 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
On magnetic guidance of charged particles
High precision beta decay experiments with polarized neutrons, employing magnetic guiding fields for the decay electrons in combination with energy dispersive detectors, initiated detailed studies of the point spread function (PSF) for homogeneous ...
H. Backe
doaj +1 more source
Prospecting the protein design landscape
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Long-Ranged Oppositely Charged Interactions for Designing New Types of Colloidal Clusters
Getting control over the valency of colloids is not trivial and has been a long-desired goal for the colloidal domain. Typically, tuning the preferred number of neighbors for colloidal particles requires directional bonding, as in the case of patchy ...
Ahmet Faik Demirörs +6 more
doaj +1 more source
The radial motions of the charged test particles in the field of a spherically symmetric charged object in general relativity are considered and their classification is built.
V. D. Gladush, M. V. Galadgyi
doaj +1 more source
Forest fires in Europe from July 22-25, 2009 [PDF]
According to the official data of the FAO, in 43% of cases it is unknown how forest fires come about. By analyzing the available data, a hypothesis has been tested according to which such situations are a result of the connection between the burning of ...
Radovanović M.
doaj +1 more source

