Results 91 to 100 of about 229,576 (293)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Congestion management for urban EV charging systems

We consider the problem of managing Electric Vehicle (EV) charging at charging points in a city to ensure that the load on the charging points remains within the desired limits while minimizing the inconvenience to EV owners.
Rigas, Emmanouil, Bassiliades, Nick, Ramchurn, Sarvapali, Koutitas, Georgios   +3 more
core   +1 more source

Efficient Bidirectional Wireless Power Transfer System Control Using Dual Phase Shift PWM Technique for Electric Vehicle Applications

IEEE Access
The emerging bidirectional wireless power transfer (BWPT) technology provides improved flexibility without requiring human intervention by facilitating smooth Grid to Vehicle (G2V) and Vehicle to Grid (V2G) operations.
Murugan Venkatesan, R. Narayanamoorthi, Kareem M. AboRas, Ahmed Emara   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A model-based online mechanism with pre-commitment and its application to electric vehicle charging [PDF]

, 2012
We introduce a novel online mechanism that schedules the allocation of an expiring and continuously-produced resource to self-interested agents with private preferences.
Robu, V, Jennings, Nick, Gerding, E, Stein, Sebastian, Jennings, Nicholas R., Gerding, Enrico, Jennings, N, Robu, Valentin, Stein, S   +8 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Analysis of the radius and diameter protocols in terms of pricing telecommunication services

Vojnotehnički Glasnik, 2013
Accounting of telecommunication services is closely related to the functions of authentication and authorization. These functions are usually considered together and implemented within the same server using a common protocol.
Vesna M. Radonjić, Andrijana N. Todosijević, Milica R. Petrović, Mirjana D. Stojanović, Aleksandra M. Kostić-Ljubisavljević   +4 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Methodological Improvements With Conductive Materials for Volume Imaging of Neural Circuits by Electron Microscopy

Frontiers in Neural Circuits, 2018
Recent advancements in electron microscope volume imaging, such as serial imaging using scanning electron microscopy (SEM), have facilitated the acquisition of three-dimensional ultrastructural information of biological samples.
Huy Bang Nguyen, Huy Bang Nguyen, Huy Bang Nguyen, Truc Quynh Thai, Truc Quynh Thai, Yang Sui, Yang Sui, Morio Azuma, Ken Fujiwara, Nobuhiko Ohno, Nobuhiko Ohno   +10 more
doaj   +1 more source