Results 41 to 50 of about 27,797 (265)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A Heuristic-Driven Charging Strategy of Electric Vehicle for Grids with High EV Penetration

Energies, 2023
The widespread adoption of electric vehicles (EVs) poses challenges associated with charging infrastructures and their impact on the electrical grid. To address these challenges, smart charging approaches have emerged as a key solution that optimizes ...
Bahman Ahmadi, Elham Shirazi
doaj   +1 more source

Exit Strategies for Charged tRNA from GluRS [PDF]

Journal of Molecular Biology, 2010
For several class I aminoacyl-tRNA synthetases (aaRSs), the rate-determining step in aminoacylation is the dissociation of charged tRNA from the enzyme. In this study, the following factors affecting the release of the charged tRNA from aaRSs are computationally explored: the protonation states of amino acids and substrates present in the active site ...
Alexis, Black Pyrkosz, John, Eargle, Anurag, Sethi, Zaida, Luthey-Schulten   +3 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Using Partial-Charging Strategies to Adapt EV Charging Stations to Dynamic Queuing Conditions: An Agent-Based Modeling

World Electric Vehicle Journal
Modern electric vehicle (EV) charging stations must increase their adaptability to dynamic demand patterns driven by users’ heterogeneous charging behaviors, which often result in high spatial–temporal fluctuations.
Jianxin Zhang, Mingyang Yin, Xinyue Li, Fubo Li, Xinyi Zhang, Li Li   +5 more
doaj   +1 more source

PEV’s Smart Charging Strategy Based on Individual State of Charge

Eletrônica de Potência, 2023
Themain contribution of this work is a smart-charging strategy based on the state of charge analyses to avoid the undervoltages caused by plug-in electric vehicles into the distribution system. The work uses power hardware-in-the-loop simulations, where a modified IEEE 34 bus system, with five groups of electric vehicle stations, is modeled in a real-
Frederico Haasis, Oscar Solano, Bruno França, Daniel Dias   +3 more
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Multi-Objective Optimization of Parking Charging Strategy for Extended-Range Hybrid Electric Vehicle Based on MOMSA

World Electric Vehicle Journal
Extended-range hybrid electric vehicles (E-RHEVs) require optimized parking charging strategies that consider both charging time and battery health.
Rong Yang, Jianxiang Lu, Zhiqi Sun, Wei Huang   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source