Results 261 to 270 of about 2,176,838 (331)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

open access: yesAdvanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac   +7 more
wiley   +1 more source

Spatially Controlled 3‐D Multiplexed Aptamer Patterning in Hydrogels

open access: yesAdvanced Materials Interfaces, EarlyView.
A hydrogel platform based on norbornene‐functionalized polyvinyl alcohol enables high‐resolution, 3‐D multiplexed patterning of DNA aptamers via two‐photon polymerization. Two distinct aptamers are covalently immobilized with single micron‐scale precision across the x, y, and z dimensions.
Kevin Roost   +9 more
wiley   +1 more source

Fabrication and Characterization of PEDOT:PSS‐Based Microstructured Electrodes for In Vitro Cell Culture

open access: yesAdvanced Materials Interfaces, EarlyView.
Poly(3,4‐ethylenedioxythiophene) poly(styrene sulfonate) (PEDOT:PSS)‐based microstructured electrodes are fabricated using vacuum soft lithography as an alternative to conventional methods. This novel fabrication approach enables the production of scalable and cost‐effective bioelectronic devices.
Gema del Rocio Lopez‐Buenafe   +7 more
wiley   +1 more source

Tailoring Electrochemical Properties of PEDOT‐Based Platinum Electrode via Controlled Polymerization in Simulated Physiological Conditions

open access: yesAdvanced Materials Interfaces, EarlyView.
This study systematically optimizes the polymerization parameters of poly(3,4‐ethylenedioxythiophene) (PEDOT) coatings for neural electrodes. By evaluating electrochemical performance, morphology, and stability, we identify optimal conditions to achieve low impedance, high charge storage capacity, and superior current‐injection limits, providing a ...
Mohammad Taghi Tourchi Moghadam   +1 more
wiley   +1 more source

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