Results 111 to 120 of about 892,099 (304)

Successful Treatment of Myasthenia Gravis Following PD-1/CTLA-4 Combination Checkpoint Blockade in a Patient With Metastatic Melanoma

Frontiers in Oncology, 2019
Currently, the blockade of certain immune checkpoints such as the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death-1 (PD-1) using checkpoint inhibitors is standard of care in patients with metastatic melanoma, especially ...
Jan-Michael Werner, Viola Schweinsberg, Michael Schroeter, Michael Schroeter, Boris von Reutern, Michael P. Malter, Max Schlaak, Max Schlaak, Gereon R. Fink, Gereon R. Fink, Cornelia Mauch, Cornelia Mauch, Norbert Galldiks, Norbert Galldiks, Norbert Galldiks   +14 more
doaj   +1 more source

The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function [PDF]

, 2005
During mitosis, the spindle assembly checkpoint (SAC) responds to faulty attachments between kinetochores and the mitotic spindle by imposing a metaphase arrest until the defect is corrected, thereby preventing chromosome missegregation. A genetic screen
Vanoosthuyse, V., Hardwick, Kevin, Kadura, Sheila, Sazer, Shelley, He, Xiangwei, Vanoosthuyse, Vincent, Hardwick, Kevin G   +6 more
core   +1 more source

G9a Inhibition Enhances Checkpoint Inhibitor Blockade Response in Melanoma

, 2021
Purpose:G9a histone methyltransferase exerts oncogenic effects in several tumor types and its inhibition promotes anticancer effects. However, the impact on checkpoint inhibitor blockade response and the utility of G9a or its target genes as a biomarker ...
Kamal, Nabilah Ahmad, Gannon, Frank, Lee, Jason S., Wilmott, James S., Ferguson, Blake, Silva, Ines P., Al-Ejeh, Fares, Rao, Sudha, McCuaig, Robert, Pritchard, Antonia L., Long, Georgina, V, Ali, Sayed, Scolyer, Richard A., Hayward, Nicholas K., Kelly, Gregory M., Casciello, Francesco   +15 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Single-cell landscape of bronchoalveolar immune cells in patients with immune checkpoint inhibitor-related pneumonitis

npj Precision Oncology
The pathophysiology of immune checkpoint inhibitor-related pneumonitis remains incompletely understood. We conducted single-cell and T-cell receptor transcriptomic sequencing on the bronchoalveolar lavage fluid from five patients with grade ≥2 immune ...
Zhening Zhang, Lei Zhang, Keqiang Wang, Tong Xie, Xiaotian Zhang, Wenyi Yu, Yanyan Li, Lin Shen, Ran Li, Zhi Peng   +9 more
doaj   +1 more source

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis [PDF]

, 2007
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors.
Newton, Ian P., Clarke, Alan Richard, Jamieson, TJ, Sansom, Owen, Nathke, Inke S.; id_orcid, Alan Clarke, Newton, IP, Clarke, A, Ian P. Newton, Owen Sansom, Thomas J. Jamieson, Dikovskaya, D, Meniel, V, Kroboth, K, Sansom, O, Dikovskaya, Dina, Oakley, A, Oakley, Abigail, Abigail Oakley, Nathke, IS, Schiffmann, D, Valerie Meniel, Clarke, Alan, Schiffmann, David, Kroboth, Karin, David Schiffmann, Nathke, Inke S., Sansom, Owen J., Dina Dikovskaya, Inke S. Näthke, Karin Kroboth, Meniel, Valerie, Jamieson, Thomas J.   +32 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Whole-body CT scanning radiation improves the immune microenvironment of tumor tissues to enhance the antitumor effect of ICI

BMC Cancer
Objective The effect of frequent whole-body CT scans during immune checkpoint inhibitor (ICI) therapy on patients' anti-tumor immunity. Methods We conducted a retrospective clinical study aimed to investigate the correlation between the frequency of CT ...
Jigang Dong, Ying Qi, Sha Sha, Chengrui Fu, Xiao Xu, Baosheng Li   +5 more
doaj   +1 more source

BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer

Cell Reports, 2017
Summary: PARP inhibition is known to be an effective clinical strategy in BRCA mutant cancers, but PARP inhibition has not been applied to BRCA-proficient tumors.
Sergey Karakashev, Hengrui Zhu, Yuhki Yokoyama, Bo Zhao, Nail Fatkhutdinov, Andrew V. Kossenkov, Andrew J. Wilson, Fiona Simpkins, David Speicher, Dineo Khabele, Benjamin G. Bitler, Rugang Zhang   +11 more
doaj   +1 more source

Nek family of kinases in cell cycle, checkpoint control and cancer [PDF]

, 2011
Early studies in lower Eukaryotes have defined a role for the members of the NimA related kinase (Nek) family of protein kinases in cell cycle control. Expansion of the Nek family throughout evolution has been accompanied by their broader involvement in ...
Haider Nasir, Nasir Haider, Stambolic Vuk, Previn Dutt, Moniz, L, Larissa Moniz, Dutt Previn, Dutt, P, Haider, N, Stambolic, V, Moniz Larissa, Vuk Stambolic, Haider, Nasir, Dutt, Previn, Moniz, Larissa, Stambolic, Vuk   +15 more
core   +1 more source