Results 211 to 220 of about 182,514 (265)

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

Rituximab for the treatment of immune checkpoint inhibitor-induced glomerulonephritis. [PDF]

Clin Kidney J
Alasadi Y, Garcia JC, Arani N, Page V, Geng Y, Andersen CR, Tchakarov A, Kitchlu A, Mamlouk O, Abudayyeh A.   +9 more
europepmc   +1 more source

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

Immune checkpoint inhibitor-related myocarditis in patients with thymic epithelial tumors: a retrospective cohort analysis. [PDF]

Cancer Immunol Immunother
Zeng H, Kang J, Pu S, Dai C, Jiang J, Chen Y, Chen Y, Fu L, Liu H, Guo M, Yi H, Chen H, Zhong W, Xue Y.   +13 more
europepmc   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Combined immune checkpoint inhibitor-induced type 1 diabetes: a rare but serious endocrinopathy. [PDF]

JCEM Case Rep
Emami K, Goyal S, Akula V, Amoakohene P.
europepmc   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Targeting MLCK1 uncouples immune checkpoint inhibitor-induced colitis from antitumour immunity. [PDF]

Gut
Xiong L, Huang J, Dong Y, Han W, Kuo WT, Xu W, Han Y, An C, Zhu R, Zhu N, Xia H, Rahman A, Tang S, Jiang C, Zhao J, Pei W, Wang J, Wang X, Song J, Wang Z, Wu S, Zhang H, Xu H, Wu B, Huang Q, Bao B, Mei Q, Zhu H, Hou L, Liangpunsakul S, Cao F, Weng H, Tan B, Turner JR, Wang H, Zuo L.   +35 more
europepmc   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Peripheral blood DNA methylation profile and immune checkpoint inhibitor response in cancer patients. [PDF]

ESMO Open
Kleinberger M, Sunder-Plassmann V, Starzer AM, Tomasich E, Zierfuss C, Niederdorfer B, Berger JM, Gottmann L, Solano Henao I, Korpan M, Fuerst J, Feldmann K, Englisch C, Ay C, Haslacher H, Furtner J, Preusser M, Heller G, Berghoff AS.   +18 more
europepmc   +1 more source