Results 241 to 250 of about 892,099 (304)

Immune hallmarks of recurrent immune checkpoint inhibitor-mediated inflammatory arthritis. [PDF]

Cancer Immunol Res
Keam S, Li YJ, Chu Y, Tayar JH, Lu H, Wu M, Agarwal SK, Jain N, Msaouel P, Diab A, Wang L, Haymaker C, Nurieva R, Kim ST.   +13 more
europepmc   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Immune checkpoint inhibitor-related myocarditis in a patient with hepatocellular carcinoma: a case report. [PDF]

Front Cardiovasc Med
Zhou Y, Zhang Z, Liu S, Nan J, Zhang Z, Chen Z.   +5 more
europepmc   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

The Dyspnea Dilemma: Immune Checkpoint Inhibitor-Associated Myocarditis Mimicking Overlapping Cardiac Pathologies-A Case Report. [PDF]

Case Rep Cardiol
Javed N, Itare V, Ashraf S, Allu SVV, Jadhav P.   +4 more
europepmc   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Immune checkpoint inhibitor-induced eosinophilic fasciitis: A pharmacovigilance and EADV Task force study. [PDF]

J Eur Acad Dermatol Venereol
Bruijn TVM, Gérard AO, Labat M, Apalla Z, Binsbergen WV, Koumaki D, Rivet V, Dezoteux F, Giacchero D, Ardern-Jones MR, Heelan K, Hirner JP, Mayor A, Labots M, Starink MV, Laken CJV, Sibaud V, Elshot YS.   +17 more
europepmc   +1 more source

Immune Checkpoint Inhibitor Therapy of Malignancy in Kidney Transplant Recipients: Analysis of Real-world Outcomes. [PDF]

Transplant Direct
Rezazadeh A, Barbir EB, Aboelatta MA, Haivas CD, Kavousi S, Smith BH, Kukla A, Dudek AZ.   +7 more
europepmc   +1 more source

Immune checkpoint inhibitor-based combinatory and alternative strategies for immune treatment of lung cancers. [PDF]

Front Immunol
Park JY, Kwak CH, Chang YC, Kim CH.
europepmc   +1 more source