Results 81 to 90 of about 892,099 (304)
Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes [PDF]
, 2007 The spindle checkpoint delays anaphase onset until all chromosomes have attached in a bi-polar manner to the mitotic spindle. Mad and Bub proteins are recruited to unattached kinetochores, and generate diffusible anaphase inhibitors.
Rischitor, Patricia E +8 more
core +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Check this checkpoint inhibitor in lymphoma [PDF]
Blood, 2017 In this issue of Blood , Zinzani et al 1 report that the immune check point inhibitor pembrolizumab is active against relapsed/refractory primary mediastinal large B-cell lymphoma (PMLBCL). This unique clinicopathologic entity accounts for up to 10% of all diffuse large B-cell lymphomas (DLBCLs) and is most commonly seen in females between 20 and 40 ...
Fernando Cabanillas, Noridza Rivera
openaire +2 more sources
Human checkpoint proteins hRad9, hHus1, and hRad1 form a DNA damage-responsive complex [PDF]
, 2004 Human cells have evolved protective mechanisms such as DNA repair and cell cycle checkpoints in order to promote stability of the genome. Studies on hereditary instability syndromes associated with a higher incidence of malignancies like Xeroderma ...
Volkmer, Elias
core +1 more source
Successful treatment of immune checkpoint inhibitor-related periaortitis [PDF]
We report a 64-year-old patient with melanoma receiving ipilimumab and nivolumab therapy who presented with a periaortic soft tissue mass around the abdominal aorta on restaging fluorodeoxyglucose positron emission tomography/computed tomography imaging.
Özdemir, Berna C +7 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The landscape of checkpoint inhibitors in oncology
European Journal of CancerImmune checkpoint inhibitor (ICI) therapies have become increasingly popular treatment options for patients with cancer, even for patients in non-metastatic settings. Survival and responses have been reported for individual tumor types, but little is known about these outcomes, collectively. We sought to provide an overview of overall survival (OS) and
Haslam, Alyson +3 more
openaire +4 more sources
Cost‐effectiveness and financial risks associated with immune checkpoint inhibitor therapy [PDF]
, 2020 The reimbursement of immune checkpoint inhibitor is challenging. Funding these technologies involves the careful balance between awarding innovation and ensuring affordability as increases in drug spending compete directly with other health care and ...
Kim, H +8 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Commentary: The checkpoint before checkpoint inhibitors [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2020 William A, Blessing, Yolonda L, Colson
openaire +2 more sources