Results 101 to 110 of about 1,216,970 (284)

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

Advanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang, Xiangyang Zhan, Jiexiang Zhang, Mingyue Tan, Chuanmin Chu, Guanqun Ju, Xinyu Zhai, Jianyi Gu, Huirong Zhu, Dongliang Xu   +9 more
wiley   +1 more source

Agent-Based Computing and Programming of Agent Systems

, 2006
The concepts of autonomous agent and multi-agent system provide appropriate levels of abstraction for the design, implementation and simulation of many complex, distributed computational systems, particularly those systems open to external participants ...
McBurney, P, Michael Luck, Gonzalez-Palacios, J, Peter McBurney, Luck, M, Jorge Gonzalez-Palacios   +5 more
core   +2 more sources

Dispersive liquid-liquid microextraction (DLLME) combined with graphite furnace atomic absorption spectrometry (GFAAS) for determination of trace Cu and Zn in water Samples

E3S Web of Conferences, 2014
Dispersive liquid-liquid microextraction (DLLME) combined with graphite furnace atomic absorption spectrometry (GFAAS) was proposed for the determination of trace amounts of Copper and Zinc ions using 8-hydroxyquinoline (8-HQ) as chelating agent. Several
Ghorbani A., Arabi F., Aflaki F., Emami Meibodi A.   +3 more
doaj   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Formal Specification of Multi-Agent Systems

, 1995
In this paper the framework DESIRE, originally designed for formal specification of complex reasoning systems is used to specify a real-world multi-agent application on a conceptual level.
Keplicz, BD, Jennings, N. R., Brazier, FMT, Treur, J, Keplicz, B. D., Jennings, NR, Treur, J., Brazier, F. M. T.   +7 more
core  

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

The Interaction Parameter in Binary Surfactant Mixtures of a Chelating Surfactant and a Foaming Agent

, 2010
The micellisation in binary mixed surfactant systems of a chelating surfactant and a foaming agent has been studied by surface tension measurements in order to calculate the interaction parameter (beta).
Fredrik Andersson, Håkan Edlund, Erik Hedenström, Andersson, Fredrik,, Norgren, Magnus,, Högberg, Ida,, Ida Högberg, Magnus Norgren, Hedenström, Erik,, Edlund, Håkan,   +9 more
core   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Hydrophilic Chelating Resin Based on Acrolein Copolymer

Chelating resin containing iminodiacetic acid functional groups has been synthesized by the reaction of amination and subsequent carboxymethylation of highly cross-linked acrolein copolymer.
Krilova, Valentīna, Cimdiņš, Rūdolfs, Bērziņa-Cimdiņa, Līga   +2 more
core  

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source