Chelerythrine Chloride Downregulates β-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma [PDF]
Molecules, 2020 Plant secondary metabolites have been seen as alternatives to seeking new medicines for treating various diseases. Phytochemical scientists remain hopeful that compounds isolated from natural sources could help alleviate the leading problem in oncology ...
Win Sen Heng, Shiau-Chuen Cheah
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Chelerythrine Chloride: A Potential Rumen Microbial Urease Inhibitor Screened by Targeting UreG [PDF]
International Journal of Molecular Sciences, 2021 Inhibition of ruminal microbial urease is of particular interest due to its crucial role in regulating urea-N utilization efficiency and nitrogen pollution in the livestock industry. Acetohydroxamic acid (AHA) is currently the only commercially available urease inhibitor, but it has adverse side effects.
Shengguo Zhao, Nan Zheng
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Evaluating Chelerythrine Chloride as a Potential Treatment for Multidrug-Resistant Gonorrhea [PDF]
Infection and Drug ResistanceRan Zhang,1,2,* Yuqiu Qi,2,* Hui Peng,2,* Chenlong Tao,2,3 Songwei Lu,2 Qiankun Ke,2 Shangzhu Shen,2 Zhuo Wang,1,2 Xiaomian Lin1,2,4 1Department of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, People’s Republic ...
Zhang R +8 more
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Chelerythrine Chloride Alleviated Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Glycolytic Pathway Through Targeting Glyceraldehyde-3-Phosphate Dehydrogenase [PDF]
MoleculesAcute lung injury (ALI) is a fatal respiratory disease caused by excessive inflammation. Chelerythrine chloride (CH), an isoquinoline alkaloid, exhibits diverse biological activities. The research focused on assessing CH’s therapeutic effects against LPS-
Yuting He +9 more
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Chelerythrine chloride from Macleaya cordata induces growth inhibition and apoptosis in human gastric cancer BGC-823 cells [PDF]
Acta Pharmaceutica Sinica B, 2012 This study aimed to investigate the ability of chelerythrine chloride (CHE), the main active ingredient of Macleaya cordata, to induce apoptosis in human gastric cancer BGC-823 cells. The results demonstrate that CHE inhibits cell proliferation in a time-
Zhengfu Zhang +4 more
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Chelerythrine Chloride Inhibits Stemness of Melanoma Cancer Stem-Like Cells (CSCs) Potentially via Inducing Reactive Oxygen Species and Causing Mitochondria Dysfunction. [PDF]
Comput Math Methods Med, 2022 Growing evidence has demonstrated that high heterogeneity contributes to poor prognosis and malignancies. The existence of melanoma cancer stem-like cells (CSCs), which are a small subpopulation of melanoma cells, is responsible for tumour resistance to therapies.
Li H, He M, Zhao P, Liu P, Chen W, Xu X.
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Antiviral effect of chelerythrine chloride against tick-borne encephalitis virus [PDF]
Virology JournalTick-borne encephalitis virus (TBEV) is a neurotropic Orthoflavivirus that causes severe encephalitis and long-term neurological sequelae. Due to the limited protection from existing vaccines and the absence of effective antiviral drugs, the prevention ...
Jiangdan Li +11 more
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Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines.
Oncol Lett, 2016 Previous studies have demonstrated that the benzo[c]phenanthridine alkaloid chelerythrine chloride (CC) has inhibitory effects on various tumors. However, the anticancer activity of CC and its underlying mechanisms have not been elucidated in renal cancer cells.
Chen XM +4 more
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Discovering bioactive pharmaceuticals from natural products for type 2 diabetes mellitus using network pharmacology, molecular docking, and molecular dynamics [PDF]
Scientific ReportsType 2 diabetes mellitus (T2DM) is a global health challenge that requires new therapeutic approaches. Natural compounds from botanical sources offer promise as alternative treatments due to their multifaceted bioactivity and favourable safety profiles ...
Bita Rahmani +5 more
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Antibacterial activity and mechanism of chelerythrine against Streptococcus agalactiae
Frontiers in Veterinary ScienceStreptococcus agalactiae (S.agalactiae), also known as group B Streptococcus (GBS), is a highly infectious pathogen. Prolonged antibiotic usage leads to significant issues of antibiotic residue and resistance. Chelerythrine (CHE) is a naturally occurring
Jige Xin +7 more
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