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An Update of the Sanguinarine and Benzophenanthridine Alkaloids’ Biosynthesis and Their Applications [PDF]

open access: yesMolecules, 2022
Benzophenanthridines belong to the benzylisoquinolic alkaloids, representing one of the main groups of this class. These alkaloids include over 120 different compounds, mostly in plants from the Fumariaceae, Papaveraceae, and Rutaceae families, which ...
Felipe Vázquez-Flota
exaly   +7 more sources

Hypecoum spp.—Chemistry and Biological Activity of Alkaloids

open access: yesDiversity, 2023
Genus Hypecoum Tourn. ex L. belongs to the poppy family Papaveraceae and comprises about 19 species occurring in Europe, Northern Africa and Asia.
Nadezhda Kostova, Tsvetelina Doncheva
doaj   +2 more sources

Insights on Antitumor Activity and Mechanism of Natural Benzophenanthridine Alkaloids

open access: yesMolecules, 2023
Benzophenanthridine alkaloids are a class of isoquinoline compounds, which are widely found in the plants of papaveraceae, corydalis, and rutaceae. Biological activities and clinical studies have shown that benzophenanthridine alkaloids have inhibitory ...
Rui Peng   +13 more
doaj   +3 more sources

Dynamic Interconversions of Single Molecules Probed by Recognition Tunneling at Cucurbit[7]uril‐Functionalized Supramolecular Junctions

open access: yesAngewandte Chemie, Volume 134, Issue 26, June 27, 2022., 2022
Dynamic conversions of single molecules can be monitored at doubly cucurbit[7]uril‐functionalized supramolecular junctions. Through this intermolecular recognition tunneling technique, the molecular conductance of different analytes and analyte mixtures can be finger‐printed in dependence on pH and competitive salts, showcasing the first examples of ...
Bohuai Xiao   +8 more
wiley   +2 more sources

Sanguinarine reductase, a key enzyme of benzophenanthridine detoxification [PDF]

open access: yesPlant, Cell & Environment, 2005
ABSTRACTCultured cells of Eschscholzia californica respond to a yeast glycoprotein elicitor by producing benzophenanthridine alkaloids, which are excreted into the cell wall and the outer medium. These compounds, preferentially sanguinarine, are efficient phytoalexins because of their ability to intercalate double‐stranded DNA (dsDNA), penetrate ...
Dagmar, Weiss   +3 more
openaire   +4 more sources

Chemical Characterization of Corydalis chaerophylla D.C. Extracts and Preliminary Evaluation of Their in Vitro and in Vivo Biological Properties

open access: yesChemistry &Biodiversity, Volume 20, Issue 12, December 2023., 2023
Abstract Genus Corydalis is a rich source of isoquinoline alkaloids reported to having potential bioactivities. Corydalis chaerophylla collected from Nepal at an altitude of 2400–4800 m was extracted using hexane, methanol and chloroform as solvents. The resulting hexane, methanol and chloroform extracts were subjected to LC–DAD‐MSn analysis to yield ...
Binita Maharjan   +7 more
wiley   +1 more source

Comparative effects of medium‐chain fatty acids or phytobiotics‐based feed additives on performance, caecum microbiota, volatile fatty acid production and intestinal morphology of broilers

open access: yesVeterinary Medicine and Science, Volume 9, Issue 6, Page 2719-2730, November 2023., 2023
This manuscript aims to investigate different herbal feed additives as alternative to antibiotic growth promoters (AGPs). For this purpose, medium‐chain fatty acids (MCFAs) or phytobiotics (essential oils [EOs] and alkaloids [ALKs]) and blended feed additives have been used.
Necmettin Ceylan   +5 more
wiley   +1 more source

Advances in the natural α‐glucosidase inhibitors

open access: yeseFood, Volume 4, Issue 5, October 2023., 2023
Natural products are a great source for the development of new α‐glucosidase (AG) inhibitory drug candidates. We aim to summarize advances in natural AG inhibitors according to their secondary metabolite groups in the last decade. Their mechanisms of action and structure–activity relationships will especially be discussed.
Didem Şöhretoğlu   +4 more
wiley   +1 more source

Safety and efficacy of a feed additive consisting of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit® extra) for all poultry species (excluding laying and breeding birds) (Phytobiotics Futterzusatzstoffe GmbH)

open access: yesEFSA Journal, Volume 21, Issue 6, June 2023., 2023
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit® Extra) when used as a zootechnical feed additive (functional group: other zootechnical additives) for all poultry species (excluding laying and breeding ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)   +23 more
wiley   +1 more source

Highly Chemoselective One‐Step Synthesis of Novel N‐Substituted‐Pyrrolo[3,4‐b]quinoline‐1,3‐diones via Palladium‐Catalyzed Aminocarbonylation/Carbonylative Cyclisation Sequence

open access: yesEuropean Journal of Organic Chemistry, Volume 26, Issue 10, March 7, 2023., 2023
While common methods giving access to N‐substituted‐pyrrolo‐[3,4‐b]‐quinoline‐1,3‐diones consist of multistep synthesis involving quinoline‐based substrates, a broadly applicable one‐step palladium‐catalyzed carbonylative imidization‐cyclization process has been developed starting from 3‐bromo‐2‐iodoquinoline, that opens new perspectives for the ...
Sami Chniti   +4 more
wiley   +1 more source

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