Results 1 to 10 of about 475 (114)

An Update of the Sanguinarine and Benzophenanthridine Alkaloids’ Biosynthesis and Their Applications [PDF]

Molecules, 2022
Benzophenanthridines belong to the benzylisoquinolic alkaloids, representing one of the main groups of this class. These alkaloids include over 120 different compounds, mostly in plants from the Fumariaceae, Papaveraceae, and Rutaceae families, which ...
Felipe Vázquez-Flota, Vázquez-Flota Felipe   +1 more
exaly   +6 more sources

Insights on Antitumor Activity and Mechanism of Natural Benzophenanthridine Alkaloids

Molecules, 2023
Benzophenanthridine alkaloids are a class of isoquinoline compounds, which are widely found in the plants of papaveraceae, corydalis, and rutaceae. Biological activities and clinical studies have shown that benzophenanthridine alkaloids have inhibitory ...
Rui Peng, Mengwei Xu, Baocheng Xie, Qing Min, Siwen Hui, Ziwei Du, Yan Liu, Wei Yu, Shi Wang, Xin Chen, Guang Yang, Zhaofang Bai, Xiaohe Xiao, Shuanglin Qin   +13 more
doaj   +3 more sources

Hypecoum spp.—Chemistry and Biological Activity of Alkaloids

Diversity, 2023
Genus Hypecoum Tourn. ex L. belongs to the poppy family Papaveraceae and comprises about 19 species occurring in Europe, Northern Africa and Asia.
Nadezhda Kostova, Tsvetelina Doncheva
doaj   +1 more source

Sanguinarine reductase, a key enzyme of benzophenanthridine detoxification [PDF]

Plant, Cell & Environment, 2005
ABSTRACTCultured cells of Eschscholzia californica respond to a yeast glycoprotein elicitor by producing benzophenanthridine alkaloids, which are excreted into the cell wall and the outer medium. These compounds, preferentially sanguinarine, are efficient phytoalexins because of their ability to intercalate double‐stranded DNA (dsDNA), penetrate ...
Dagmar, Weiss, Alfred, Baumert, Matthias, Vogel, Werner, Roos   +3 more
openaire   +4 more sources

Isolation and identification of alkaloids from Macleaya microcarpa by UHPLC–Q-TOF-MS and their cytotoxic activity in vitro, antiangiogenic activity in vivo

BMC Chemistry, 2020
Background Extensive bioactivities of alkaloids from the genus Macleaya (Macleaya cordata (Willd.) R. Br. and Macleaya microcarpa (Maxim.) Fedde) have been widely reported, as well as more and more concerned from the scientific communities.
Chunmei Sai, Jian’an Wang, Binjie Li, Lin Ding, Huiyun Wang, Qibao Wang, Huiming Hua, Fangpeng Zhang, Qiang Ren   +8 more
doaj   +1 more source

Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma [PDF]

Biochemical Pharmacology, 2009
This study was aimed at evaluating the potential application of benzophenanthridine alkaloids, sanguinarine and cheleritrine, in the therapy of melanoma cancer. In vitro antiproliferative activity of sanguinarine was higher than that of cheleritrine against the B16 melanoma 4A5 cells.
De Stefano, Ilaria, Raspaglio, Giuseppina, Zannoni, Gian Franco, Travaglia, Daniele, Prisco, Mg, Mosca, M, Ferlini, Cristiano, Scambia, Giovanni, Gallo, Daniela   +8 more
openaire   +3 more sources

Toxicological Effects of Berberine and Sanguinarine

Frontiers in Molecular Biosciences, 2018
Berberine and Sanguinarine alkaloids belong to a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms. This group also includes some related compounds with neutral or weakly acidic properties. Alkaloids are produced by
Nitika Singh, Bechan Sharma
doaj   +1 more source

The Elevation of LC-ESI-Q-TOF-MS Response in the Analysis of Isoquinoline Alkaloids from Some Papaveraceae and Berberidaceae Representatives

Journal of Analytical Methods in Chemistry, 2017
Twenty-five methanol extracts obtained from various representatives of Papaveraceae and Berberidaceae botanical families (genera: Papaver, Argemone, Eschscholzia, Chelidonium, Glaucium, and Berberis) were screened for their alkaloid content in an ...
Wirginia Kukula-Koch
doaj   +1 more source

Photoredox catalysed reductive aminomethylation of quaternary benzophenanthridine alkaloids

Natural Product Research, 2022
Reduction of C = N double bond is the most important phase I metabolism process of quaternary benzophenanthridine alkaloids (QBAs). Inspired by the NADPH mediated reduction in QBAs, a visible-light promoted reductive aminomethylation of QBAs for synthesis of 6-substituted benzophenanthridines was reported using QBAs and N,N-dimethylaniline as coupling ...
Xinhao, Wang, Lin, Wang, Jingxuan, Zhang, Yisong, Liu, Hongqi, Xie, Jianguo, Zeng, Pi, Cheng   +6 more
openaire   +2 more sources

Synthesis and Antileukemia Activity Evaluation of Benzophenanthridine Alkaloid Derivatives

Molecules, 2022
Thirty-three benzophenanthridine alkaloid derivatives (1a–1u and 2a–2l) were synthesized, and their cytotoxic activities against two leukemia cell lines (Jurkat Clone E6-1 and THP-1) were evaluated in vitro using a Cell Counting Kit-8 (CCK-8) assay.
Yaling Tang, Xinglian Xu, Jiang Li, Lulu Deng, Shuzhen Mu   +4 more
openaire   +3 more sources