Results 21 to 30 of about 625 (182)

Research Progress on G‐Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
The upregulation telomerase activity is observed in over 85‐90% of human cancers and provides an attractive target for cancer therapies. The high guanine content in the telomere DNA sequences and the hTERT promoter can form G‐quadruplexes (G4s). Small molecules targeting G4s in telomeres and hTERT promoter could stabilize the G4s and inhibit hTERT ...
Wei Gu, Zihan Lin, Shengchao Zhao, Guanzhen Wang, Ziyi Shen, Wei Liu, Yi Cai, Kaibo Wang, Chunpeng Craig Wan, Tingdong Yan, Milena Georgieva   +10 more
wiley   +1 more source

Distribution of Therapeutic Efficacy of Ranunculales Plants Used by Ethnic Minorities on the Phylogenetic Tree of Chinese Species

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
The medicinal properties of plants can be evolutionarily predicted by phylogeny‐based methods, which, however, have not been used to explore the regularity of therapeutic effects of Chinese plants utilized by ethnic minorities. This study aims at exploring the distribution law of therapeutic efficacy of Ranunculales plants on the phylogenetic tree of ...
Da-Cheng Hao, Yulu Zhang, Chun-Nian He, Pei-Gen Xiao, Jelena Zivkovic   +4 more
wiley   +1 more source

Isolation and identification of alkaloids from Macleaya microcarpa by UHPLC–Q-TOF-MS and their cytotoxic activity in vitro, antiangiogenic activity in vivo

BMC Chemistry, 2020
Background Extensive bioactivities of alkaloids from the genus Macleaya (Macleaya cordata (Willd.) R. Br. and Macleaya microcarpa (Maxim.) Fedde) have been widely reported, as well as more and more concerned from the scientific communities.
Chunmei Sai, Jian’an Wang, Binjie Li, Lin Ding, Huiyun Wang, Qibao Wang, Huiming Hua, Fangpeng Zhang, Qiang Ren   +8 more
doaj   +1 more source

Come-back of phenanthridine and phenanthridinium derivatives in 21st century [PDF]

, 2014
Phenanthridine derivatives are one of the most intensively studied families of biologically active compounds with efficient DNA binding ; attracting attention about time of DNA structure discovery (1960ies), early recognized as a symbol of DNA ...
Piantanida, Ivo, Radić Stojković, Marijana, Tumir, Lidija-Marija   +2 more
core   +2 more sources

BHLH IRIDOID SYNTHESIS 3 is a member of a bHLH gene cluster regulating terpenoid indole alkaloid biosynthesis in Catharanthus roseus

Plant Direct, Volume 5, Issue 1, January 2021., 2021
Abstract Basic helix‐loop‐helix (bHLH) transcription factors (TFs) are key regulators of plant specialized metabolites, including terpenoid indole alkaloids (TIAs) in Catharanthus roseus. Two previously characterized subgroup‐IVa bHLH TFs, BIS1 (bHLH Iridoid Synthesis 1) and BIS2 regulate iridoid biosynthesis in the TIA pathway.
Sanjay Kumar Singh, Barunava Patra, Priyanka Paul, Yongliang Liu, Sitakanta Pattanaik, Ling Yuan   +5 more
wiley   +1 more source

Zanthoxylum zanthoxyloides Alkaloidal Extract Improves CCl4‐Induced Hepatocellular Carcinoma‐Like Phenotypes in Rats

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Background. Despite the enrollment of new small molecules such as Sorafenib for the treatment of hepatocellular carcinoma (HCC), HCC still remains a significant contributor to cancer‐related mortality and morbidity globally. Zanthoxylum zanthoxyloides is long suspected of possessing anticancer bioactive compounds that may hold the prospect of ...
Desmond Omane Acheampong, Isaac Kyei Baffour, Victor Yao Atsu Barku, Justice Kwaku Addo, Mainprice Akuoko Essuman, Alex Boye, Sakineh Kazemi Noureini   +6 more
wiley   +1 more source

Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma [PDF]

Biochemical Pharmacology, 2009
This study was aimed at evaluating the potential application of benzophenanthridine alkaloids, sanguinarine and cheleritrine, in the therapy of melanoma cancer. In vitro antiproliferative activity of sanguinarine was higher than that of cheleritrine against the B16 melanoma 4A5 cells.
De Stefano, Ilaria, Raspaglio, Giuseppina, Zannoni, Gian Franco, Travaglia, Daniele, Prisco, Mg, Mosca, M, Ferlini, Cristiano, Scambia, Giovanni, Gallo, Daniela   +8 more
openaire   +3 more sources

Alkaloids as Potential Phytochemicals against SARS‐CoV‐2: Approaches to the Associated Pivotal Mechanisms

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Since its inception, the coronavirus disease 2019 (COVID‐19) pandemic has infected millions of people around the world. Therefore, it is necessary to find effective treatments against Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2), as it is the viral source of COVID‐19.
Mohammad Bagher Majnooni, Sajad Fakhri, Gholamreza Bahrami, Maryam Naseri, Mohammad Hosein Farzaei, Javier Echeverría, Shih-Chao Lin   +6 more
wiley   +1 more source

Toxicological Effects of Berberine and Sanguinarine

Frontiers in Molecular Biosciences, 2018
Berberine and Sanguinarine alkaloids belong to a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms. This group also includes some related compounds with neutral or weakly acidic properties. Alkaloids are produced by
Nitika Singh, Bechan Sharma
doaj   +1 more source

The Elevation of LC-ESI-Q-TOF-MS Response in the Analysis of Isoquinoline Alkaloids from Some Papaveraceae and Berberidaceae Representatives

Journal of Analytical Methods in Chemistry, 2017
Twenty-five methanol extracts obtained from various representatives of Papaveraceae and Berberidaceae botanical families (genera: Papaver, Argemone, Eschscholzia, Chelidonium, Glaucium, and Berberis) were screened for their alkaloid content in an ...
Wirginia Kukula-Koch
doaj   +1 more source