Results 21 to 30 of about 494 (132)

A New Benzophenanthridine Alkaloid from Caloncoba Glauca [PDF]

Natural Product Communications, 2017
Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure of the new compound was elucidated from spectroscopic and mass spectrometric evidence. This is the first report of alkaloids from the genus Caloncoba.
Jabar B P A A, Agbo, James D S, Mpetga, Raphael, Bikanga, Roland T, Tchuenguem, Rolande B N, Tsafack, Maurice D, Awouafack, Jean P, Dzoyem, Takuya, Ito, Hiroyuki, Morita, Pierre, Tane   +9 more
openaire   +2 more sources

N-Methoxycarbonyl-9,12-Dimethoxy-Norchelerythrine: A Novel Antifungal Type-III Benzo[c]phenanthridine from Zanthoxylum simulans Hance Seedlings

Molbank
Zanthoxylum simulans Hance, commonly known as Sichuan pepper, is a well-known medicinal plant recognized for its potential as a source of bioactive specialized metabolites.
Diego Cárdenas-Laverde, Diego Quiroga, Ericsson Coy-Barrera   +2 more
doaj   +1 more source

The Ca2+‐CAMTA6‐PP2C49‐HKT1;1 signaling axis modulates ion homeostasis during Arabidopsis seed germination under salt stress

The Plant Journal, Volume 127, Issue 1, July 2026.
SUMMARY Soil salinization severely constrains seedling establishment by disrupting cellular Na+/K+ homeostasis. Calcium (Ca2+) signaling contributes to the re‐establishment of ion balance during early growth, yet the mechanisms linking Ca2+ perception to ion transport regulation remain unclear.
Yvonne Kiere, Ancy E. J. Chandran, Guy Sobol, Omer Cremer, Shaked Azoulay‐Portal, Yonatan Wexler, Doron Shkolnik   +6 more
wiley   +1 more source

Phytochemicals in Asthma Management: Mechanism, Translational Gap and Clinical Integration

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
The phytochemicals including flavonoids, alkaloids, terpenoids, and saponins modulate inflammatory, oxidative, and immune pathways in asthma. It highlights their mechanisms of action, translational challenges, advanced formulation strategies, and emerging clinical potential as adjunct therapies for precision‐based asthma management.
Pulak Majumder, Trisita Majumder
wiley   +1 more source

Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii(Rutaceae) [PDF]

Chemistry Central Journal, 2014
Zanthoxylum buesgenii is a shrub used in Sierra Leone as remedy to cure venereal diseases, arthritis, and rheumatism whereas leaves and barks are employed to treat leprosy and to relieve pain. In South West Region of Cameroon, the plant locally called "Mbem" by Lewoh-Lebang community, is orally given to patients as aphrodisiac decoction and to increase
Sandjo, Louis P, Kuete, Victor, Tchangna, Rodrigue S, Efferth, Thomas, Ngadjui, Bonaventure T   +4 more
openaire   +2 more sources

A Golgi‐localized N‐methyltransferase and reversible aldo–keto reductases coordinate dual terminal routes in galanthamine biosynthesis

The Plant Journal, Volume 126, Issue 6, June 2026.
Significant Statement This study identifies LaTMT2, a Golgi‐localized N‐methyltransferase, and three reversible aldo–keto reductases (LaAKR1 and LaAKR3) as key enzymes coordinating the dual terminal routes of galanthamine biosynthesis in Leucojum aestivum.
Basanta Lamichhane, Archana Niraula, Natacha Merindol, Sarah‐Eve Gélinas, Patrick Lagüe, Simon Ricard, Hugo Germain, Isabel Desgagné‐Penix   +7 more
wiley   +1 more source

Chinese Herbal Medicines for Diabetic Cardio‐Cerebrovascular Diseases: Key Bioactive Metabolites and Action Mechanisms

Journal of Nutrition and Metabolism, Volume 2026, Issue 1, 2026.
Currently, the global incidence of diabetes is increasing, particularly in populous developing regions. In China, over 290 million people are affected by diabetic cardio‐cerebrovascular diseases. These diseases account for more than 40% of deaths and impose a significant economic burden on both society and families.
Ying Su, Shuwen Luo, Wei Li, Cuicui Cheng, Wei Liu, Xinyu Yang, Zhen Xing, Eric Gumpricht   +7 more
wiley   +1 more source

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

World Journal of Gastrointestinal Oncology, 2016
Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis, and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti ...
GAZIANO, ROBERTA, MORONI, GABRIELLA, Buè, C, Miele, Mt, SINIBALDI VALLEBONA, PAOLA, PICA, FRANCESCA   +5 more
openaire   +4 more sources

The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 4, October 2025.
ABSTRACT Cytochrome P450 3A4 (CYP3A4) is one of the most important members of the cytochrome P450 subfamily, which is involved in the catalytic process of many drug activation or deactivation. Meanwhile, it is also a risk factor for drug‐induced toxic reactions.
Fang Wang, Xiwei Gu, Haiying Hong, Qianqian Xia, Yuxin Zhang, Ying Song, Baoxin Li, Pan Fan   +7 more
wiley   +1 more source

The Herbal Pair Polygonum hydropiper L‐Coptis chinensis Franch Attenuate DSS‐Induced Ulcerative Colitis by Modulating Metabolism and Intestinal Flora

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
PH‐CC regulates dysbiosis in intestinal flora and metabolic disorders in UC mice by reducing the abundance of specific bacterial groups, thereby alleviating inflammatory damage to the colonic mucosa and improving the overall condition of UC. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which dysbiosis of the intestinal ...
Feifei Zhu, Chenhui Ren, Keli Zhou, Xueqing Huang, Mengyu Mei, Haiyan Niu, Shouzhong Ren   +6 more
wiley   +1 more source