Results 31 to 40 of about 540 (159)

A Golgi‐localized N‐methyltransferase and reversible aldo–keto reductases coordinate dual terminal routes in galanthamine biosynthesis

The Plant Journal, Volume 126, Issue 6, June 2026.
Significant Statement This study identifies LaTMT2, a Golgi‐localized N‐methyltransferase, and three reversible aldo–keto reductases (LaAKR1 and LaAKR3) as key enzymes coordinating the dual terminal routes of galanthamine biosynthesis in Leucojum aestivum.
Basanta Lamichhane, Archana Niraula, Natacha Merindol, Sarah‐Eve Gélinas, Patrick Lagüe, Simon Ricard, Hugo Germain, Isabel Desgagné‐Penix   +7 more
wiley   +1 more source

Metal-Catalyzed Domino Synthesis of Benzophenanthridines and 6H‑Naphtho[2,3‑c]‑chromenes

, 2018
A new and efficient synthesis of tetracyclic phenanthridines and benzo­[c]­chromenes has been described involving a metal-mediated two-step domino strategy. The first step involved efficient palladium-catalyzed domino carbopalladation/cross coupling, and
Sandip Kundal (1393132), Swapnadeep Jalal (1393126), Baitan Chakraborty (5427506), Umasish Jana (1393129), Kartick Paul (1393123)   +4 more
core   +3 more sources

Antibacterial Activity of Zanthoxylum chalybeum, Aloe deserti, and Zanthoxylum usambarense

BioMed Research International, Volume 2026, Issue 1, 2026.
Various Gram‐positive and Gram‐negative enteric pathogens are responsible for bacterial gastroenteritis, and this condition is commonly treated with antibiotics. But, the growing prevalence of antimicrobial resistance and drug‐associated toxicities has diminished the effectiveness of conventional drugs, prompting the need for alternative remedies ...
Stephen Mugambi Maithulia, Careen Ihazano Chumba, John Muthini Maingi, David Ng’ang’a Mburu, Eliud Nyaga Mwaniki Njagi, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

Research Status and Prospects of Helicobacter pylori–associated gastritis: From Mechanisms to Traditional Chinese Medicine Treatment

Gastroenterology Research and Practice, Volume 2026, Issue 1, 2026.
Helicobacter pylori–associated gastritis (HPAG) is a chronic inflammatory condition of the gastric mucosa caused by Helicobacter pylori infection, serving as the core etiological factor for peptic ulcers and gastric precancerous lesions. Given the persistently high global infection rates and the escalating burden of antibiotic resistance, conventional ...
Zhongyao Fan, Ziling Jin, Caiyue Liu, Ruifan Hu, Weiqiang Li, Neetu Rawal   +5 more
wiley   +1 more source

Research Progress on Natural Benzophenanthridine Alkaloids and their Pharmacological Functions: A Review [PDF]

Natural Product Communications, 2016
Benzophenanthridine alkaloids belong to the benzyl isoquinoline family of alkaloids, which are mainly found in Papaveraceae and Rutaceae. To date, over 100 compounds have been isolated from natural herbal medicines which display a variety of pharmacological functions.
Na, Han, Zhiyou, Yang, Zhihui, Liu, Huijing, Liu, Jun, Yin   +4 more
openaire   +2 more sources

Chinese Herbal Medicines for Diabetic Cardio‐Cerebrovascular Diseases: Key Bioactive Metabolites and Action Mechanisms

Journal of Nutrition and Metabolism, Volume 2026, Issue 1, 2026.
Currently, the global incidence of diabetes is increasing, particularly in populous developing regions. In China, over 290 million people are affected by diabetic cardio‐cerebrovascular diseases. These diseases account for more than 40% of deaths and impose a significant economic burden on both society and families.
Ying Su, Shuwen Luo, Wei Li, Cuicui Cheng, Wei Liu, Xinyu Yang, Zhen Xing, Eric Gumpricht   +7 more
wiley   +1 more source

Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii(Rutaceae) [PDF]

Chemistry Central Journal, 2014
Zanthoxylum buesgenii is a shrub used in Sierra Leone as remedy to cure venereal diseases, arthritis, and rheumatism whereas leaves and barks are employed to treat leprosy and to relieve pain. In South West Region of Cameroon, the plant locally called "Mbem" by Lewoh-Lebang community, is orally given to patients as aphrodisiac decoction and to increase
Sandjo, Louis P, Kuete, Victor, Tchangna, Rodrigue S, Efferth, Thomas, Ngadjui, Bonaventure T   +4 more
openaire   +2 more sources

The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 4, October 2025.
ABSTRACT Cytochrome P450 3A4 (CYP3A4) is one of the most important members of the cytochrome P450 subfamily, which is involved in the catalytic process of many drug activation or deactivation. Meanwhile, it is also a risk factor for drug‐induced toxic reactions.
Fang Wang, Xiwei Gu, Haiying Hong, Qianqian Xia, Yuxin Zhang, Ying Song, Baoxin Li, Pan Fan   +7 more
wiley   +1 more source

The Herbal Pair Polygonum hydropiper L‐Coptis chinensis Franch Attenuate DSS‐Induced Ulcerative Colitis by Modulating Metabolism and Intestinal Flora

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
PH‐CC regulates dysbiosis in intestinal flora and metabolic disorders in UC mice by reducing the abundance of specific bacterial groups, thereby alleviating inflammatory damage to the colonic mucosa and improving the overall condition of UC. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which dysbiosis of the intestinal ...
Feifei Zhu, Chenhui Ren, Keli Zhou, Xueqing Huang, Mengyu Mei, Haiyan Niu, Shouzhong Ren   +6 more
wiley   +1 more source

Natural products targeting tumour angiogenesis

British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu, Lara Johanna Friedrich, Thomas Efferth   +2 more
wiley   +1 more source