Results 31 to 40 of about 494 (132)

Natural products targeting tumour angiogenesis

British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu, Lara Johanna Friedrich, Thomas Efferth   +2 more
wiley   +1 more source

Screening of Chelidonium majus isoquinoline alkaloids reveals berberine and chelidonine as selective ligands for the nuclear receptors RORβ and HNF4α, respectively

Archiv der Pharmazie, Volume 357, Issue 7, July 2024.
Since the Chelidonium majus (greater celandine) alkaloid sanguinarine has recently been characterized as a dual peroxisome proliferator‐activated receptor‐α/γ ligand, sanguinarine and structurally related alkaloids were screened on nuclear receptors. Berberine and chelidonine were identified as Chelidonium majus alkaloids with selectivity for the two ...
Sohrab Salehi, Espen Schallmayer, Nils Bandomir, Annette Kärcher, Jan‐Frederik Güth, Pascal Heitel   +5 more
wiley   +1 more source

Research Progress on Natural Benzophenanthridine Alkaloids and their Pharmacological Functions: A Review [PDF]

Natural Product Communications, 2016
Benzophenanthridine alkaloids belong to the benzyl isoquinoline family of alkaloids, which are mainly found in Papaveraceae and Rutaceae. To date, over 100 compounds have been isolated from natural herbal medicines which display a variety of pharmacological functions.
Na, Han, Zhiyou, Yang, Zhihui, Liu, Huijing, Liu, Jun, Yin   +4 more
openaire   +2 more sources

Cytotoxic Benzophenanthridine and Benzylisoquinoline Alkaloids from Argemone mexicana

Zeitschrift für Naturforschung C, 2003
Abstract Fractionation of the chloroform extract from the aerial part of Argemone mexicana led to the isolation of two benzophenanthridine-type alkaloids, N-demethyloxysanguinarine and pancorine; three benzylisoquinoline-type alkaloids, (+)-1,2,3,4-tetrahydro-1-(2-hydroxymethyl- 3,4-dimethoxyphenylmethyl)-6,7-methylenedioxyisoquinoline, (
Yuh-Chwen, Chang, Fang-Rong, Chang, Ashraf T, Khalil, Pei-Wen, Hsieh, Yang-Chang, Wu   +4 more
openaire   +2 more sources

6-Methoxydihydroavicine is a benzophenanthridine alkaloid with anti-leukemia activity

Frontiers in Pharmacology
BackgroundAcute myeloid leukemia (AML) is an aggressive hematological malignancy with limited therapeutic options. Despite recent advances in targeted therapies, patients are still faced with poor survival outcomes. Thus, development of novel therapeutic agents with broad efficacy remains an urgent need.MethodsWe conducted a natural compound library ...
Yingying Yang, Paul A. Spagnuolo
openaire   +3 more sources

The Role of the Iminium Bond in the Inhibition of Reverse Transcriptase by Quaternary Benzophenanthridines

Journal of Pharmacy and Pharmacology, 1998
AbstractThe quaternary benzo[c]phenanthridines fagaronine, nitidine and O-methylfagaronine have been reviewed as potential antitumour and antiviral agents. Their mode of action has not been established, but their ability to bind with DNA by intercalation is believed to be involved.Of the three synthetic analogues of O-methylfagaronine which we have ...
M A, Kerry, O, Duval, R D, Waigh, S P, Mackay   +3 more
openaire   +2 more sources

Progresses in Synthesis of Benzophenanthridine Alkaloids and Their Derivatives [PDF]

Chinese Journal of Organic Chemistry, 2012
Pi Cheng, Jianguo Zeng
openaire   +1 more source

Alkaloids in Future Drug Discovery. [PDF]

Molecules, 2022
Ferreira MU.
europepmc   +1 more source

Placental Passage of Humulone and Protopine in an Ex Vivo Human Perfusion System. [PDF]

Planta Med, 2021
Spiess D, Abegg VF, Chauveau A, Treyer A, Reinehr M, Oufir M, Duong E, Potterat O, Hamburger M, Simões-Wüst AP.   +9 more
europepmc   +1 more source

Identification of Sanguinarine Metabolites in Rats Using UPLC-Q-TOF-MS/MS. [PDF]

Molecules, 2023
Liu M, Liu Z, Dong Z, Zou X, Zeng J, Yang Z.   +5 more
europepmc   +1 more source