Results 31 to 40 of about 625 (182)

Photoredox catalysed reductive aminomethylation of quaternary benzophenanthridine alkaloids

Natural Product Research, 2022
Reduction of C = N double bond is the most important phase I metabolism process of quaternary benzophenanthridine alkaloids (QBAs). Inspired by the NADPH mediated reduction in QBAs, a visible-light promoted reductive aminomethylation of QBAs for synthesis of 6-substituted benzophenanthridines was reported using QBAs and N,N-dimethylaniline as coupling ...
Xinhao, Wang, Lin, Wang, Jingxuan, Zhang, Yisong, Liu, Hongqi, Xie, Jianguo, Zeng, Pi, Cheng   +6 more
openaire   +2 more sources

In vitro cytotoxic activity of african plants: a review [PDF]

, 2022
In African countries, cancer not only is a growing problem, but also a challenge because available funding and resources are limited. Therefore, African medicinal plants play a significant role in folk medicine and some of them are traditionally used for
Canga, Isabel, Castro, María Ángeles, Oliveira, Ana Isabel, Pinho, Cláudia, Vita, Pedro   +4 more
core   +2 more sources

Synthesis and Antileukemia Activity Evaluation of Benzophenanthridine Alkaloid Derivatives

Molecules, 2022
Thirty-three benzophenanthridine alkaloid derivatives (1a–1u and 2a–2l) were synthesized, and their cytotoxic activities against two leukemia cell lines (Jurkat Clone E6-1 and THP-1) were evaluated in vitro using a Cell Counting Kit-8 (CCK-8) assay.
Yaling Tang, Xinglian Xu, Jiang Li, Lulu Deng, Shuzhen Mu   +4 more
openaire   +3 more sources

Creative research in the chemical industry– four decades in retrospect [PDF]

, 2006
My professional research career spanning more than four decades has been largely devoted to synthetic medicinal chemistry (Ciba, Bombay-now Mumbai-21 years) followed by an equal number of years in process development of drugs, crop protection chemicals ...
A Guggisberg, A Guggisberg, A R Choudhury, A R Choudhury, A R Choudhury, A R Choudhury, B Anjaneyulu, B Anjaneyulu, B C Chen, B R Pai, C Fritchie, C L Stevens, C L Stevens, D Chopra, D K Ray, D K Ray, D R Ashtekar, G F Fabiola, G F Fabiola, G F Fabiola, G Govil, G Kartha, G M Whitesides, H Fuhrer, H Vogeli, J G Lombardino, K Ananda, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Nagarajan, K Rajalakshmi, Kuppuswamy Nagarajan, L Damodharan, M G Peter, R K Maller, R K Maller, R Usha, S Deepthi, S L Spassov, S Natarajan, S Natarajan, T Kametani, T R Govindachari, T R Govindachari, V Pattabhi, V Sudarasanam   +78 more
core   +1 more source

Transition-metal-catalyzed functionalization of alkynes with organoboron reagents: new trends, nechanistic insights, and applications [PDF]

, 2021
Catalytic functionalization of alkynes with organoboron reagents provides a straightforward access to stereochemically defined multisubstituted alkenes, which are structural motifs commonly found in bioactive compounds and organic materials.
Arrayás, Ramón Gómez, Carretero, Juan C., Corpas, Javier, Mauleón, Pablo   +3 more
core   +1 more source

A New Benzophenanthridine Alkaloid from Caloncoba Glauca [PDF]

Natural Product Communications, 2017
Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure of the new compound was elucidated from spectroscopic and mass spectrometric evidence. This is the first report of alkaloids from the genus Caloncoba. Sesamin (4) [MIC = 256
Jabar B P A A, Agbo, James D S, Mpetga, Raphael, Bikanga, Roland T, Tchuenguem, Rolande B N, Tsafack, Maurice D, Awouafack, Jean P, Dzoyem, Takuya, Ito, Hiroyuki, Morita, Pierre, Tane   +9 more
openaire   +2 more sources

N-Methoxycarbonyl-9,12-Dimethoxy-Norchelerythrine: A Novel Antifungal Type-III Benzo[c]phenanthridine from Zanthoxylum simulans Hance Seedlings

Molbank
Zanthoxylum simulans Hance, commonly known as Sichuan pepper, is a well-known medicinal plant recognized for its potential as a source of bioactive specialized metabolites.
Diego Cárdenas-Laverde, Diego Quiroga, Ericsson Coy-Barrera   +2 more
doaj   +1 more source

The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 4, October 2025.
ABSTRACT Cytochrome P450 3A4 (CYP3A4) is one of the most important members of the cytochrome P450 subfamily, which is involved in the catalytic process of many drug activation or deactivation. Meanwhile, it is also a risk factor for drug‐induced toxic reactions.
Fang Wang, Xiwei Gu, Haiying Hong, Qianqian Xia, Yuxin Zhang, Ying Song, Baoxin Li, Pan Fan   +7 more
wiley   +1 more source

Antioxidant and Lipoxygenase Inhibitory Activities of Essential Oils from Endemic Plants of Côte d’Ivoire: Zanthoxylum mezoneurispinosum Ake Assi and Zanthoxylum psammophilum Ake Assi [PDF]

, 2019
peer reviewedZanthoxylum mezoneurispinosum Ake Assi and Zanthoxylum psammophilum Ake Assi are species endemic to Côte d’Ivoire. In this study, we determined, for the first time, the composition and biological activities of essential oils obtained from ...
Tanoh, Amenan Evelyne, Nea, Fatimata, Kenne Kemene, Tierry, Genva, Manon, Saive, Matthew, Tonzibo, Félix, Fauconnier, Marie-Laure   +6 more
core   +1 more source

The Herbal Pair Polygonum hydropiper L‐Coptis chinensis Franch Attenuate DSS‐Induced Ulcerative Colitis by Modulating Metabolism and Intestinal Flora

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
PH‐CC regulates dysbiosis in intestinal flora and metabolic disorders in UC mice by reducing the abundance of specific bacterial groups, thereby alleviating inflammatory damage to the colonic mucosa and improving the overall condition of UC. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which dysbiosis of the intestinal ...
Feifei Zhu, Chenhui Ren, Keli Zhou, Xueqing Huang, Mengyu Mei, Haiyan Niu, Shouzhong Ren   +6 more
wiley   +1 more source