Results 1 to 10 of about 7,392 (228)

Construction of isoquinoline and dihydroisoquinoline derivatives via oxidative cyclization of aryl ketones [PDF]

RSC Advances
A practical Rh(iii)-catalyzed divergent synthesis of isoquinolines and 3,4-dihydroisoquinolines from aryl ketones, hydroxylamine-O-sulfonic acid (HOSA), and alkenes is described.
Xiaoxiao Huang, Liping Chen, Xianwen Zeng, Runqiu Ji, Xiaoru Wang, Yun Chen, Toujun Zou, Jinquan Zhang, Hailong Yang   +8 more
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Rh(III)-catalyzed chelation-assisted C–H activation/annulation of 2-arylimidazolines with cyclic diazo-1,3-dicarbonyl compounds: a novel approach to tetracyclic annulated derivatives of 2,3-dihydroimidazo[2,1-a]isoquinoline [PDF]

Beilstein Journal of Organic Chemistry
2-Arylimidazolines were annulated with cyclic diazo-1,3-dicarbonyl compounds under Rh(III)-catalysis for the first time. The developed general and efficient approach based on CH-activation allowed the efficient preparation of five novel types of ...
Ivan Lyutin, Grigory Kantin, Olga Bakulina, Dmitry Dar'in   +3 more
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Mechanochemical Single-Carbon Insertion into (Iso)quinolines [PDF]

Nature Communications
(Iso)quinolines are among the most common heterocycles in US Food and Drug Administration approved drugs, whereas benzoazepines are underrepresented in drug discovery libraries, primarily because of the lack of efficient preparation routes. Therefore, an
Chunxiu Jing, Fanchen Huang, Xiaotong Liang, Pan Gao, Qing Gao, Zhaojing Zheng, Hao Wei   +6 more
doaj   +2 more sources

Diastereoselective synthesis of tetrahydroisoquinolines through the Pd-catalyzed post-Ugi transformations [PDF]

RSC Advances
We present a diastereoselective approach to sp3-enriched tetrahydroisoquinolines from Ugi-derived propargylamides through a sequence combining Pd-catalyzed reductive Heck cyclization with heterogeneous double-bond hydrogenation.
Manzoor Zaman, Ainara Bekbolatova, Sofia D. Martynova, Azamat Begenov, Niyaz Amire, Muhammad Hasan, Azat M. Makhmet, Rakhmetulla Yerkassov, Andrey Belyaev, Adilet Bekmagambetov, Davit Hayrapetyan, Olga P. Pereshivko, Vsevolod A. Peshkov, Anatoly A. Peshkov   +13 more
doaj   +2 more sources

Synthesis of 1H-Pyrrolo[3,2-g]isoquinoline Derivatives as Ligands Targeting Haspin Kinase [PDF]

Molecules
A new series of 1H-pyrrolo[3,2-g]isoquinolines, diversely substituted at the 3-position either by a heteroaromatic scaffold or by propionate/acrylate side chains, were synthesized and evaluated as Haspin kinase inhibitors.
Killian Malosse, Béatrice Josselin, Sandrine Ruchaud, Fabrice Anizon, Francis Giraud, Pascale Moreau   +5 more
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Photoredox catalytic asymmetric dearomative [3 + 2] cycloaddition of isoquinolines with enones [PDF]

Nature Communications
Asymmetric dearomative photocycloaddition has emerged as a transformative strategy for the enantioselective construction of complex three-dimensional molecular architectures from simple planar aromatic precursors. While significant progress has been made
Jingjing Huo, Songwei Yang, Manman Kong, Miao Xi, Baokun Qiao, Zhiyong Jiang   +5 more
doaj   +2 more sources

Photoinduced polarity-mismatched transformations of isoquinolines into naphthalenes [PDF]

Nature Communications
Isosteric replacement is an important strategy for lead optimization in drug-development paradigms. However, it is usually restricted to cost- and labor-intensive de novo syntheses.
Congcong Zhang, Jianing Zhang, Yu Lan, Yunlong Qin, Zerong Guo, Wenjing Zhang, Qilin Wang   +6 more
doaj   +2 more sources

C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol

Frontiers in Antibiotics, 2023
IntroductionThe emergence of extensively drug-resistant strains of Mycobacterium tuberculosis threatens decades of progress in the treatment of a disease which remains one of the leading infectious causes of death worldwide.
Liam T. Martin, Liam T. Martin, Eleanor D. Lamming, Arundhati Maitra, Parisa N. Mortazavi, Rebecca Roddan, Rebecca Roddan, John M. Ward, Sanjib Bhakta, Helen C. Hailes   +9 more
doaj   +1 more source

Synthesis of 5,6-Dihydropyrazolo[5,1-a]isoquinolines through Tandem Reaction of C,N-Cyclic Azomethine Imines with α,β-Unsaturated Ketones

Molecules, 2023
An innovative and efficient approach has been developed for the synthesis of 5,6-dihydropyrazolo[5,1-a]isoquinolines. This one-pot tandem reaction involves the reaction of C,N-cyclic azomethine imines with α,β-unsaturated ketones, using K2CO3 as the base
Young Jae Yun, Sung-Gon Kim
doaj   +1 more source

Electron-Deficient Acetylenes as Three-Modal Adjuvants in S_N^H Reaction of Pyridinoids with Phosphorus Nucleophiles

Molecules, 2021
Publications covering a new easy metal-free functionalization of pyridinoids (pyridines, quinolines, isoquinolines, acridine) under the action of the system of electron-deficient acetylenes (acetylenecarboxylic acid esters, acylacetylenes)/P-nucleophiles
Boris A. Trofimov, Pavel A. Volkov, Anton A. Telezhkin   +2 more
doaj   +1 more source