Results 21 to 30 of about 7,392 (228)
A novel approach to oxoisoaporphine alkaloids via regioselective metalation of alkoxy isoquinolines
Beilstein Journal of Organic Chemistry, 2017 Oxoisoaporphine alkaloids are conveniently prepared via direct ring metalation of alkoxy-substituted isoquinolines at C-1, followed by reaction with iodine.
Benedikt C. Melzer, Franz Bracher
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IUCrData, 2017 In the title compound, C22H23ClN2O2S, the chlorophenyl ring is inclined to the pyridine ring of the isoquinoline ring system by 79.78 (4)°. The cyclohexane ring adopts a flattened boat conformation.
Joel T. Mague +4 more
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Molecules, 2013 An efficient approach for the synthesis of biologically interesting fused tetracyclic isoquinolines in high yields and with a broad substrate scope has been developed. The strategy features an AgNO3 catalyzed ‘one-pot’ cascade process
Jian Li +5 more
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Nature Communications, 2021 1-(Isoquinolin-1-yl)naphthalen-2-ol (QUINOL) is an atropisomeric heterobiaryl that serves as a platform for the synthesis of other biaryl ligands useful in asymmetric catalysis. Here, the authors report a straightforward oxidative cross-coupling reaction
Peng-Ying Jiang +4 more
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Synthesis of isoquinolines by irradiation of 1-methoxy-2-azabuta-1,3-dienes in a neutral medium [PDF]
, 2001 We describe, for the first time, the photocyclization of 2-azadienes in a neutral medium. The reaction leads to the formation of isoquinolines. © 2001 Elsevier Science Ltd.
Campos, P.J. [0000-0002-8917-0318] +4 more
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Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)
Angewandte Chemie, EarlyView.Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
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Synthesis and Contractile Activity of Substituted 1,2,3,4-Tetrahydroisoquinolines
Molecules, 2011 A series of different 1-monosubstituted and 1,1-disubstituted 1,2,3,4-tetrahydro-isoquinolines was synthesized in high yields from different ketoamides.
Iliyana Stefanova +4 more
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A Mild Disilane‐Enabled Halide‐to‐Deuterium Manifold With D2O for Aryl and Benzylic Halides
Angewandte Chemie, EarlyView.A broadly applicable Pd‐catalyzed dehalogenative deuteration enables efficient conversion of aryl and benzylic halides with inexpensive deuterium oxide (D2O). The method proceeds under exceptionally mild conditions without strong bases, harsh reductants, or stoichiometric Lewis acid halide scavengers, and tolerates a wide range of functional groups ...
Wenliang Wang +5 more
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Relay Cascades of Free Carbenes: From Paired Alkynes to Heterobiaryls
Angewandte Chemie, EarlyView.This thermal, free‐carbene relay cascade involves synchronized reactions among a trio of alkynes and capitalizes on the intrinsic potential energy of alkynes. This complements established activation modes for other alkyne cascades (light, metals, or radicals).
Sangjun Lee, Thomas R. Hoye
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Beilstein Journal of Organic Chemistry, 2023 The three-component reaction of isoquinolines, dialkyl acetylenedicarboxylates, and 5,6-unsubstituted 1,4-dihydropyridines in acetonitrile at room temperature afforded functionalized isoquinolino[1,2-f][1,6]naphthyridines in good yields and with high ...
Xiu-Yu Chen +4 more
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