Results 21 to 30 of about 7,156 (173)
Molecules, 2021 Publications covering a new easy metal-free functionalization of pyridinoids (pyridines, quinolines, isoquinolines, acridine) under the action of the system of electron-deficient acetylenes (acetylenecarboxylic acid esters, acylacetylenes)/P-nucleophiles
Boris A. Trofimov +2 more
doaj +1 more source
Nitrogen atom insertion into indenes to access isoquinolines [PDF]
, 2022 We report a convenient protocol for a nitrogen atom insertion into indenes to afford isoquinolines. The reaction uses a combination of commercially available (diacetoxy¬iodo)benzene (PIDA) and ammonium carbamate to furnish a wide range of isoquinolines ...
Ori, Green +5 more
core +2 more sources
A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B
Molecules, 2022 Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield).
Ahmad K. Haidar +6 more
doaj +1 more source
Silver-Mediated Electrosynthesis of Substituted Isoquinolines via Cyclization of 2‑Ethynylbenzaldehydes [PDF]
ACS OmegaEliakin S. de Borba +7 more
doaj +2 more sources
Oxidation and hydrogenation of benzo[g]isoquinolines
, 2020 The oxidation of methyl-substituted (in the pyridine and benzene rings) benzo[g]isoquinolines to substituted 2-azaanthraquinones was realized. It was established that the pyridine ring is partially reduced to give 1,2,3,4-tetrahydrobenzo[g]isoquinolines ...
Kirillova L.M. +3 more
core +2 more sources
Recent Advances in the Synthesis of Isoquinoline-Fused Benzimidazoles
Molecules, 2022 This review includes recent developments in the synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines with particular attention given to categorizing protocols based on the structural features of the ring architecture and crystallographically characterized ...
Dylan J. Twardy +3 more
doaj +1 more source
Dibenzo[a,f]quinolizines: syntheses and cytostatic activity in estrogen-sensitive tumor cells [PDF]
, 1994 A number of methoxy-substituted 7,11b,12,13-tetrahydro-6H-dibenzo-[a,f]quinolizines with short alkyl groups in position 6 or 12 were synthesized by the Bischler-Napieralski reaction using the appropriate starting material followed by a second ring ...
Wiegrebe, Wolfgang +4 more
core +1 more source
Nitration of Pyrrolo[2,1‑a]isoquinolines
, 2023 We have successfully modified a series of pyrrolo[2,1-a]isoquinolines via direct nitration under mild reaction conditions. Easily accessible nitrates including CAN, Cu(NO3)2·H2O, and Fe(NO3)3·9H2O all can serve as effective nitrating reagents for ...
Xiao-Hui Chen (543865) +6 more
core +1 more source
Synthesis and Antifungal Evaluation of Isoquinoline-3-amide Derivatives Containing a Phenoxypyridine Moiety for Plant Protection. [PDF]
Chem BiodiversThe splicing of phenoxypyridine moieties to isoquinolin‐3‐carboxylic acid enhanced its biological activity against plant pathogenic fungi. Among target compounds, compound X6 demonstrated significant antifungal activity against Botrytis cinerea in vitro and in vivo assays, Molecular docking, molecular dynamics simulations, as well as SDH enzyme assay ...
Zhang J +7 more
europepmc +2 more sources
IUCrData, 2017 In the title compound, C22H23ClN2O2S, the chlorophenyl ring is inclined to the pyridine ring of the isoquinoline ring system by 79.78 (4)°. The cyclohexane ring adopts a flattened boat conformation.
Joel T. Mague +4 more
doaj +1 more source