Results 21 to 30 of about 6,842 (226)
Molecules, 2021 Publications covering a new easy metal-free functionalization of pyridinoids (pyridines, quinolines, isoquinolines, acridine) under the action of the system of electron-deficient acetylenes (acetylenecarboxylic acid esters, acylacetylenes)/P-nucleophiles
Boris A. Trofimov +2 more
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A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B
Molecules, 2022 Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield).
Ahmad K. Haidar +6 more
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Oxidation and hydrogenation of benzo[g]isoquinolines
, 2020 The oxidation of methyl-substituted (in the pyridine and benzene rings) benzo[g]isoquinolines to substituted 2-azaanthraquinones was realized. It was established that the pyridine ring is partially reduced to give 1,2,3,4-tetrahydrobenzo[g]isoquinolines ...
Kirillova L.M. +3 more
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Recent Advances in the Synthesis of Isoquinoline-Fused Benzimidazoles
Molecules, 2022 This review includes recent developments in the synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines with particular attention given to categorizing protocols based on the structural features of the ring architecture and crystallographically characterized ...
Dylan J. Twardy +3 more
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Nitration of Pyrrolo[2,1‑a]isoquinolines
, 2023 We have successfully modified a series of pyrrolo[2,1-a]isoquinolines via direct nitration under mild reaction conditions. Easily accessible nitrates including CAN, Cu(NO3)2·H2O, and Fe(NO3)3·9H2O all can serve as effective nitrating reagents for ...
Xiao-Hui Chen (543865) +6 more
core +1 more source
IUCrData, 2017 In the title compound, C22H23ClN2O2S, the chlorophenyl ring is inclined to the pyridine ring of the isoquinoline ring system by 79.78 (4)°. The cyclohexane ring adopts a flattened boat conformation.
Joel T. Mague +4 more
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Molecules, 2013 An efficient approach for the synthesis of biologically interesting fused tetracyclic isoquinolines in high yields and with a broad substrate scope has been developed. The strategy features an AgNO3 catalyzed ‘one-pot’ cascade process
Jian Li +5 more
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Nitrogen atom insertion into indenes to access isoquinolines
, 2022 We report a convenient protocol for a nitrogen atom insertion into indenes to afford isoquinolines. The reaction uses a combination of commercially available (diacetoxy¬iodo)benzene (PIDA) and ammonium carbamate to furnish a wide range of isoquinolines ...
Ori, Green +5 more
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A novel approach to oxoisoaporphine alkaloids via regioselective metalation of alkoxy isoquinolines
Beilstein Journal of Organic Chemistry, 2017 Oxoisoaporphine alkaloids are conveniently prepared via direct ring metalation of alkoxy-substituted isoquinolines at C-1, followed by reaction with iodine.
Benedikt C. Melzer, Franz Bracher
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Nature Communications, 2021 1-(Isoquinolin-1-yl)naphthalen-2-ol (QUINOL) is an atropisomeric heterobiaryl that serves as a platform for the synthesis of other biaryl ligands useful in asymmetric catalysis. Here, the authors report a straightforward oxidative cross-coupling reaction
Peng-Ying Jiang +4 more
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