Results 41 to 50 of about 9,595 (219)
Beilstein Journal of Organic Chemistry, 2018 Highly-substituted isoquinolines are important scaffolds in syntheses of natural products and in drug development and hence, effective synthetic approaches are required.
Benedikt C. Melzer +2 more
doaj +1 more source
Molecules, 2021 Developing an efficient catalytic system using molecular oxygen as the oxidant for rhodium-catalyzed cross-dehydrogenative coupling remains highly desirable.
Weihui Zhuang +3 more
doaj +1 more source
Asymmetric Electrophilic alpha-Amidoalkylation, VII1): Generation, Crystal Structure, and Trapping Reactions of a Chiral 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Derived N-Acyliminium Ion [PDF]
, 1990 The camphanic acid amide 4 has efficiently been oxidized with triphenylcarbenium tetrafluoroborate (3) to yield the chiral N-acyliminium ion 1. Trapping reactions of 1 with the silyl nucleophiles 7a-c and 10a-f proceeded with stereoselective bond ...
Aledesanmi +15 more
core +1 more source
Iridium-Catalyzed, Silyl-Directed, peri -Borylation of C−H Bonds in Fused Polycyclic Arenes and Heteroarenes [PDF]
, 2018 peri-Disubstituted naphthalenes exhibit interesting physical properties and unique chemical reactivity, due to the parallel arrangement of the bonds to the two peri-disposed substituents.
Hartwig, John F, Su, Bo
core +1 more source
Dibenzo[a,g]quinolizin-8-ones: synthesis, estrogen receptor affinities, and cytostatic activity [PDF]
, 1992 A number of acetoxy-substituted dibenzo[a,g]quinolizin-8-ones were synthesized by the reaction of 1-oxoisoquinolines with substituted homophthalic acid anhydride.
Angerer, S. von +4 more
core
A straightforward synthesis of indazolo[3,2-a]isoquinolin-6-amines [PDF]
, 2013 4-Substituted 1-bromoisoquinolin-3-amines were subjected to Suzuki coupling with o-nitrophenylboronic acid to yield 1-(2-nitrophenyl) isoquinolinamines, which participated in Cadogan cyclization with triethyl phosphite under microwave irradiation in a ...
Balog, József +2 more
core +1 more source
In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation
Angewandte Chemie International Edition, EarlyView.Chromophore engineering of isoquinoline aldehydes generates TICT‐based fluorogenic dyes for in situ labeling of diverse (bio)molecules with large Stokes shifts compatible with cell imaging. ABSTRACT Simple, efficient transformations of fluorogenic nature that proceed under biocompatible conditions without the formation of byproducts are of high ...
Dongchen Du +7 more
wiley +1 more source
Nature Communications, 2019 Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral ...
Qian Xiong +4 more
doaj +1 more source
Asymmetric addition of chiral boron-ate complexes to cyclic iminium ions [PDF]
, 2014 Boron-ate complexes derived from enantioenriched secondary benzylic boronic esters and aryl lithiums have been reacted with quinolinium, pyridinium and dihydroisoquinolinium salts to give enantioenriched heterocyclic structures with very high ...
Aggarwal, Varinder K. +4 more
core +2 more sources
Angewandte Chemie International Edition, EarlyView.The use of transition‐metal catalysts and design of chiral ligands have allowed chemists to access highly functionalized benzofused 5‐ and 6‐ membered rings in high yield and enantioselectivity. A common strategy used relies on an intermolecular carbometalation across alkynes and olefins, usually followed by a subsequent intramolecular carbometalation.
Clara Jans +3 more
wiley +1 more source