Results 41 to 50 of about 6,842 (226)
Molecules, 2002 Different types of novel 1,2-disubstituted 1,2-dihydro isoquinolines were synthesized by addition reactions of organolithium, alcoholates and borohydride reagents with various isoquinolinium salts.
Jean Pierre Bazureau +1 more
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Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]isoquinolines
Molecules, 2022 A new series of pyrazolo[3,4-g]isoquinoline derivatives, diversely substituted at the 4- or 8-position, were synthesized. The results of the kinase inhibitory potency study demonstrated that the introduction of a bromine atom at the 8-position was ...
Mathilde Defois +8 more
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Acta Crystallographica Section C Crystal Structure Communications, 2012 The title compound, C9H8N2, presents two almost identical independent molecules in the asymmetric unit, both of them exhibiting an extremely planar isoquinoline core (maximum r.m.s. deviation = 0.014 Å). The most significant deviation is found in the –NH2groups, which present a noticeable pyramidalization around the N atom, a feature also present in ...
Maria Atria, Ana +2 more
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Synthesis of Substituted Isoquinolines by Electrophilic Cyclization of Iminoalkynes
, 2016 The tert-butylimines of o-(1-alkynyl)benzaldehydes and analogous pyridinecarbaldehydes have been cyclized under very mild reaction conditions in the presence of I2, ICl, PhSeCl, PhSCl, and p-O2NC6H4SCl to give the corresponding halogen-, selenium-, and ...
Qinhua Huang (1309500) +2 more
core +4 more sources
Beilstein Journal of Organic Chemistry, 2017 Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke–Blackburn–Bienaymé reaction followed by a gold-catalyzed cyclization ...
Taofeng Shao +4 more
doaj +1 more source
Anti-Alphaviral Alkaloids: Focus on Some Isoquinolines, Indoles and Quinolizidines
Molecules, 2022 The discovery and the development of safe and efficient therapeutics against arthritogenic alphaviruses (e.g., chikungunya virus) remain a continuous challenge.
Anne-Laure Sandenon Seteyen +5 more
doaj +1 more source
Dissociative Photoionization of Quinoline and Isoquinoline [PDF]
The Journal of Physical Chemistry A, 2015 Two nitrogen-containing polycyclic aromatic hydrocarbon isomers of C9H7N composition, quinoline, and isoquinoline have been studied by imaging photoelectron photoion coincidence spectroscopy at the VUV beamline of the Swiss Light Source. High resolution threshold photoelectron spectra have been recorded and are interpreted applying a Franck-Condon ...
Bouwman, J. +4 more
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Copper-Catalyzed Domino Three-Component Benzannulation: Access to Isoquinolines
, 2022 We report herein the synthesis of isoquinolines through a copper(I)-catalyzed domino reaction. During this transformation, three molecules of terminal alkynes, 2-bromoaryl aldehydes (ketones), and acetamide react together, in a sequence including ...
Jianhui Wang (617970) +2 more
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Biosynthesis of Isoquinoline Alkaloids [PDF]
Planta Medica, 1979 The isoquinoline alkaloids and their biosynthetic relatives include many compounds which show important physiological properties in animals: dopamine, mescaline, morphine, papaverine, and narcotine are pertinent examples. The biosynthetic routes to the members of this family start from the essential aminoacids tyrosine or phenylalanine. Decarboxylation
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Dibenzo[a,f]quinolizines: syntheses and cytostatic activity in estrogen-sensitive tumor cells
, 1994 A number of methoxy-substituted 7,11b,12,13-tetrahydro-6H-dibenzo-[a,f]quinolizines with short alkyl groups in position 6 or 12 were synthesized by the Bischler-Napieralski reaction using the appropriate starting material followed by a second ring ...
Wiegrebe, Wolfgang +4 more
core +1 more source