Results 41 to 50 of about 7,392 (228)

Controllable stepwise fluorine elimination strategy for the chemodivergent synthesis of pyrido[2,1-

Green Synthesis and Catalysis
A controllable stepwise fluorine elimination strategy has been reported, and used to selectively produce fluoro-substituted pyrido[2,1- a ]isoquinolines and fluorine-free pyrido[2,1- a ]isoquinolines through transition-metal-free formal [3 + 3 ...
Qiuyun Li, Zili Liu, Rujing Li, Xiaoyue Zhang, Kelu Yan, Yannan Zhu, Xiang Wang, Zhongfei Han, Wen-Juan Hao, Bo Jiang   +9 more
doaj   +1 more source

Aminomethylation/hydrogenolysis as an alternative to direct methylation of metalated isoquinolines – a novel total synthesis of the alkaloid 7-hydroxy-6-methoxy-1-methylisoquinoline

Beilstein Journal of Organic Chemistry, 2018
Highly-substituted isoquinolines are important scaffolds in syntheses of natural products and in drug development and hence, effective synthetic approaches are required.
Benedikt C. Melzer, Jan G. Felber, Franz Bracher   +2 more
doaj   +1 more source

Anti-Alphaviral Alkaloids: Focus on Some Isoquinolines, Indoles and Quinolizidines

Molecules, 2022
The discovery and the development of safe and efficient therapeutics against arthritogenic alphaviruses (e.g., chikungunya virus) remain a continuous challenge.
Anne-Laure Sandenon Seteyen, Emmanuelle Girard-Valenciennes, Axelle Septembre-Malaterre, Philippe Gasque, Pascale Guiraud, Jimmy Sélambarom   +5 more
doaj   +1 more source

Photochemical Regiodivergent Functionalization of Quinolines with Aryl Ketones

Advanced Science, EarlyView.
A photocatalytic system‐controlled approach enables regiodivergent C2‐ and C4‐functionalization of quinolines with aryl ketones by optimizing aryl thiol photocatalysts and formate reductants. Using ortho‐(isopropoxycarbonyl)thiophenol with excess formate facilitates C4‐dearomatization, yielding bridged 1,3‐oxazepanes. In contrast, meta‐(methoxycarbonyl)
Yi‐Lin Zhao, Bei‐Bei Zhang, Xueying Guo, Kui Dong, Zhi‐Xiang Wang, Li‐Zhu Wu, Qiang Liu   +6 more
wiley   +1 more source

Aryl Radical Cyclizations of 1-(2‘-Bromobenzyl)isoquinolines with AIBN−Bu₃SnH:  Formation of Aporphines and Indolo[2,1-a]isoquinolines

, 2016
Radical cyclization of alkoxy-substituted 1-(2‘-bromobenzyl)-3,4-dihydroisoquinolines 1 with AIBN−Bu3SnH gave 6a,7-dehydroaporphines 2 preferentially.
Shiho Uchiito (2476501), Kazuhiko Orito (2358016), Rika Harada (3062520), Yoshitaka Satoh (1889563), Masao Tokuda (2358013), Takashi Tatsuzawa (3075573)   +5 more
core   +1 more source

Biosynthesis of Isoquinoline Alkaloids [PDF]

Planta Medica, 1979
The isoquinoline alkaloids and their biosynthetic relatives include many compounds which show important physiological properties in animals: dopamine, mescaline, morphine, papaverine, and narcotine are pertinent examples. The biosynthetic routes to the members of this family start from the essential aminoacids tyrosine or phenylalanine. Decarboxylation
openaire   +2 more sources

Suzuki Cross-Coupling/Reductive Debenzyloxycarbonylation Sequence for the Syntheses of [c]Annulated Isoquinolines: Application for the Syntheses of Pancratistatin-like Isoquinolines

, 2016
A two-step strategy involving Suzuki cross-coupling of boronic acids with a diverse array of α-iodoenones followed by hydrogenation is developed for the construction of [c]annulated isoquinolines.
Madhesan Balakrishnan (2413840), Ganesh Pandey (1520503)   +1 more
core   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions

Nature Communications, 2019
Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral ...
Qian Xiong, Shunxi Dong, Yushuang Chen, Xiaohua Liu, Xiaoming Feng   +4 more
doaj   +1 more source

Spasmolytic Activity of 1,3-Disubstituted 3,4-Dihydroisoquinolines

Biomedicines
This article concerns the spasmolytic activities of some novel 1,3-disubstituted 3,4-dihydroisoquinolines. These compounds can be evaluated as potential therapeutic candidates according to Lipinski’s rule of five, showing high gastrointestinal absorption
Miglena Milusheva, Mihaela Stoyanova, Vera Gledacheva, Iliyana Stefanova, Mina Todorova, Stoyanka Nikolova   +5 more
doaj   +1 more source