Results 51 to 60 of about 7,156 (173)

Synthesis of Substituted Isoquinolines by Electrophilic Cyclization of Iminoalkynes

, 2016
The tert-butylimines of o-(1-alkynyl)benzaldehydes and analogous pyridinecarbaldehydes have been cyclized under very mild reaction conditions in the presence of I2, ICl, PhSeCl, PhSCl, and p-O2NC6H4SCl to give the corresponding halogen-, selenium-, and ...
Qinhua Huang (1309500), Richard C. Larock (1353099), Jack A. Hunter (3031452)   +2 more
core   +4 more sources

Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions

Nature Communications, 2019
Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral ...
Qian Xiong, Shunxi Dong, Yushuang Chen, Xiaohua Liu, Xiaoming Feng   +4 more
doaj   +1 more source

Rhodium-Catalyzed Oxidative Annulation of 2- or 7-Arylindoles with Alkenes/Alkynes Using Molecular Oxygen as the Sole Oxidant Enabled by Quaternary Ammonium Salt

Molecules, 2021
Developing an efficient catalytic system using molecular oxygen as the oxidant for rhodium-catalyzed cross-dehydrogenative coupling remains highly desirable.
Weihui Zhuang, Jiaqi Zhang, Yanping Zheng, Qiufeng Huang   +3 more
doaj   +1 more source

Copper-Catalyzed Domino Three-Component Benzannulation: Access to Isoquinolines

, 2022
We report herein the synthesis of isoquinolines through a copper­(I)-catalyzed domino reaction. During this transformation, three molecules of terminal alkynes, 2-bromoaryl aldehydes (ketones), and acetamide react together, in a sequence including ...
Jianhui Wang (617970), Peng Ma (3089811), Yuhang Wang (332111)   +2 more
core   +1 more source

Spasmolytic Activity of 1,3-Disubstituted 3,4-Dihydroisoquinolines

Biomedicines
This article concerns the spasmolytic activities of some novel 1,3-disubstituted 3,4-dihydroisoquinolines. These compounds can be evaluated as potential therapeutic candidates according to Lipinski’s rule of five, showing high gastrointestinal absorption
Miglena Milusheva, Mihaela Stoyanova, Vera Gledacheva, Iliyana Stefanova, Mina Todorova, Stoyanka Nikolova   +5 more
doaj   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

THE SYNTHESIS OF SOME ISOQUINOLINES

, 1949
A number of new isoquinolines substituted in the benzene nucleus have been prepared. The substituents include hydrazine-, chloro-, nitro-, and some combinations of these.
Richard H. F. Manske, Marshall Kulka
core   +1 more source

Synthesis of pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines via three-component [3 + 2] cycloaddition followed by one-pot N-allylation and intramolecular Heck reactions

Beilstein Journal of Organic Chemistry, 2020
Two kinds of [3 + 2] cycloaddition intermediates generated from the three-component reactions of 2-bromobenzaldehydes and maleimides with amino esters or amino acids were used for a one-pot N-allylation and intramolecular Heck reactions to form ...
Xiaoming Ma, Suzhi Meng, Xiaofeng Zhang, Qiang Zhang, Shenghu Yan, Yue Zhang, Wei Zhang   +6 more
doaj   +1 more source

Benzo[de]naphtho[1,8-gh]quinolines: synthesis, photophysical studies and nitro explosives detection

Chimica Techno Acta, 2021
A rational synthetic approach to substituted naphtho[1,8-gh]quinolines using intramolecular cyclization in the presence of potassium in the series of (naphthalen-1-yl)isoquinolines is described. The photophysical properties of the obtained compounds were
Igor L. Nikonov, Igor A. Khalymbadzha, Leila К. Sadieva, Maria I. Savchuk, Ekaterina S. Starnovskaya, Dmitry S. Kopchuk, Igor S. Коvalev, Grigory А. Kim, Oleg N. Chupakhin   +8 more
doaj   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source