Results 11 to 20 of about 540 (159)

Photoredox catalysed reductive aminomethylation of quaternary benzophenanthridine alkaloids

Natural Product Research, 2022
Reduction of C = N double bond is the most important phase I metabolism process of quaternary benzophenanthridine alkaloids (QBAs). Inspired by the NADPH mediated reduction in QBAs, a visible-light promoted reductive aminomethylation of QBAs for synthesis of 6-substituted benzophenanthridines was reported using QBAs and N,N-dimethylaniline as coupling ...
Xinhao, Wang, Lin, Wang, Jingxuan, Zhang, Yisong, Liu, Hongqi, Xie, Jianguo, Zeng, Pi, Cheng   +6 more
openaire   +3 more sources

Toxicological Effects of Berberine and Sanguinarine

Frontiers in Molecular Biosciences, 2018
Berberine and Sanguinarine alkaloids belong to a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms. This group also includes some related compounds with neutral or weakly acidic properties. Alkaloids are produced by
Nitika Singh, Bechan Sharma
doaj   +2 more sources

The Elevation of LC-ESI-Q-TOF-MS Response in the Analysis of Isoquinoline Alkaloids from Some Papaveraceae and Berberidaceae Representatives [PDF]

Journal of Analytical Methods in Chemistry, 2017
Twenty-five methanol extracts obtained from various representatives of Papaveraceae and Berberidaceae botanical families (genera: Papaver, Argemone, Eschscholzia, Chelidonium, Glaucium, and Berberis) were screened for their alkaloid content in an ...
Wirginia Kukula-Koch
doaj   +2 more sources

N-Methoxycarbonyl-9,12-Dimethoxy-Norchelerythrine: A Novel Antifungal Type-III Benzo[c]phenanthridine from Zanthoxylum simulans Hance Seedlings

Molbank
Zanthoxylum simulans Hance, commonly known as Sichuan pepper, is a well-known medicinal plant recognized for its potential as a source of bioactive specialized metabolites.
Diego Cárdenas-Laverde, Diego Quiroga, Ericsson Coy-Barrera   +2 more
doaj   +2 more sources

Isolation and identification of alkaloids from Macleaya microcarpa by UHPLC–Q-TOF-MS and their cytotoxic activity in vitro, antiangiogenic activity in vivo

BMC Chemistry, 2020
Background Extensive bioactivities of alkaloids from the genus Macleaya (Macleaya cordata (Willd.) R. Br. and Macleaya microcarpa (Maxim.) Fedde) have been widely reported, as well as more and more concerned from the scientific communities.
Chunmei Sai, Jian’an Wang, Binjie Li, Lin Ding, Huiyun Wang, Qibao Wang, Huiming Hua, Fangpeng Zhang, Qiang Ren   +8 more
doaj   +1 more source

Sanguinarine synergistically potentiates aminoglycoside‐mediated bacterial killing

Microbial Biotechnology, Volume 15, Issue 7, Page 2055-2070, July 2022., 2022
Aminoglycosides primarily interact with the bacterial ribosomes and result in protein misfolding and ROS production. Insertion of abnormal proteins into the cell membrane increases the membrane permeability and leads to enhanced uptake of sanguinarine.
Chang Lu, Nian Zhang, Sihoi Kou, Liangliang Gao, Bo Peng, Yunlu Dai, Jun Zheng   +6 more
wiley   +1 more source

Ring Expansion of 4-Alkynylcyclobutenones. Synthesis of Piperidinoquinones, Highly Substituted Dihydrophenanthridines, Benzophenanthridines, and the Naturally Occurring Pyrrolophenanthridine, Assoanine

, 2016
New synthetic routes to a variety of N-heterocyclic quinones and hydroquinones are described. These include thermolyses of 4-hydroxy-4-[4-N-(benzenesulfonyl)-4-aza-1,6-dialkynyl]cyclobutenones to piperidinoquinones and 4-hydroxy-4-[3-(N-phenylamino)-1 ...
Yifeng Xiong (2276353), Harold W. Moore (3003804)   +1 more
core   +2 more sources

Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma [PDF]

Biochemical Pharmacology, 2009
This study was aimed at evaluating the potential application of benzophenanthridine alkaloids, sanguinarine and cheleritrine, in the therapy of melanoma cancer. In vitro antiproliferative activity of sanguinarine was higher than that of cheleritrine against the B16 melanoma 4A5 cells.
De Stefano, Ilaria, Raspaglio, Giuseppina, Zannoni, Gian Franco, Travaglia, Daniele, Prisco, Mg, Mosca, M, Ferlini, Cristiano, Scambia, Giovanni, Gallo, Daniela   +8 more
openaire   +3 more sources

A Short Total Synthesis of Benzophenanthridine Alkaloids via a Rhodium(III)-Catalyzed CH Ring-Opening Reaction

, 2021
The biologically important naturally available benzophenanthridines were prepared efficiently in three steps with overall good yields. A new synthetic methodology involving a rhodium­(III) catalyzed redox-neutral ring-opening of 7-azabenzonorbornadienes ...
Narasingan Aravindan (11494976), Narasingan Aravindan, Masilamani Jeganmohan, Masilamani Jeganmohan (1446319)   +3 more
core   +1 more source

Rhodium(III)-Catalyzed Diastereoselective Ring-Opening of 7‑Azabenzonorbornadienes with Aromatic Ketoximes: Synthesis of Benzophenanthridine Derivatives

, 2019
A rhodium­(III)-catalyzed redox-neutral ring-opening of 7-azabenzonorbornadienes with aromatic ketoximes giving 2-arylated hydronaphthylamines in a highly diastereoselective manner is described.
Varathan Vinayagam (8038211), Mrinmoy Jana (8038214), Arumugam Mariappan (1849006), Masilamani Jeganmohan (1446319)   +3 more
core   +2 more sources