Results 51 to 60 of about 540 (159)

6-Methoxydihydroavicine is a benzophenanthridine alkaloid with anti-leukemia activity

Frontiers in Pharmacology
BackgroundAcute myeloid leukemia (AML) is an aggressive hematological malignancy with limited therapeutic options. Despite recent advances in targeted therapies, patients are still faced with poor survival outcomes. Thus, development of novel therapeutic agents with broad efficacy remains an urgent need.MethodsWe conducted a natural compound library ...
Yingying Yang, Paul A. Spagnuolo
openaire   +3 more sources

Voie d'accès aux benzophenanthridines naturelles et la chimie des composés métallo-aromatiques stables

, 2015
Recent developments on dual palladium/norbornene catalytic reactions led to one-pot synthesis of complexes polyheterocyclic molecules. By extension of this reaction, the coupling of aryl triflates and bromobenzylamines permitted us to synthesize natural ...
Deyris, Pierre-Alexandre
core  

I. Utilization of the 1-ferrocenyl-2-methylpropyl substituent as a chiral auxiliary in the asymmetric syntheses of the benzophenanthridine alkaloids (+)- and (-)-corynoline. II. The syntheses of intercalating agents with linker chains for the attachment to oligodeoxyribonucleotides

, 1988
Part I. The synthesis of optically pure (+)- and ($-$)-corynoline was achieved by the condensation reaction of the chiral Schiff bases (+)- and ($-$)-$N$-piperonylidene-1-ferrocenyl-2-methylpropylamine, S-(+)-78 and R-($-$)-78, with 3,4-(methylenedioxy ...
Chen, Jer-Kang
core   +1 more source

Síntese, caracterização e estudo da relação estrutura-atividade (REA) de chalconas e de compostos heterocíclicos biologicamente ativos em doenças negligenciadas, hiperglicemia e leucemia [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2010Buscando fundamentalmente moléculas com potencial biológico, o interesse deste estudo foi ...
Chiaradia, Louise Domeneghini
core  

Alkaloids in Future Drug Discovery. [PDF]

Molecules, 2022
Ferreira MU.
europepmc   +1 more source

Placental Passage of Humulone and Protopine in an Ex Vivo Human Perfusion System. [PDF]

Planta Med, 2021
Spiess D, Abegg VF, Chauveau A, Treyer A, Reinehr M, Oufir M, Duong E, Potterat O, Hamburger M, Simões-Wüst AP.   +9 more
europepmc   +1 more source

Progresses in Synthesis of Benzophenanthridine Alkaloids and Their Derivatives [PDF]

Chinese Journal of Organic Chemistry, 2012
Pi Cheng, Jianguo Zeng
openaire   +1 more source

Identification of Sanguinarine Metabolites in Rats Using UPLC-Q-TOF-MS/MS. [PDF]

Molecules, 2023
Liu M, Liu Z, Dong Z, Zou X, Zeng J, Yang Z.   +5 more
europepmc   +1 more source

Anti-Nasopharyngeal carcinoma mechanism of sanguinarine based on network pharmacology and molecular docking. [PDF]

Medicine (Baltimore), 2023
Fan JY, Liu J, Zhang WQ, Lin T, Hu XR, Zhou FL, Tang L, He YC, Shi HJ.   +8 more
europepmc   +1 more source

Mechanism of Formation of Heterocyclic Compounds by Reaction of Hydrazoic Acid with Cyclic Compounds: Synthesis of Benzoxazines.

, 1957
2-a-Naphthoyl- , 2-p-methoxybenzoyl-, 2-p-chlorobenzoyl-, 2-m-nitrobenzoyl-, 2-mesitoyl-, 2-phenylacetyl-, and 2-butyryl-benzoic acids, and benzylidene- and propylidene-phthalides have been subjected to the conditions of the Schmidt reaction to yield ...
Marks, Robert Edward.
core