Results 61 to 70 of about 625 (182)

ベンゾフェナンスリジン化合物を先導とする抗腫瘍性化合物の開発 [PDF]

open access: yes, 2001
金沢大学薬学部1.簡単なフェネチルアミン体とベンズアルデヒド体から、同一の合成中間体を経由するプロトベルベリン及び13-メチルプロトベルベリンの新しい簡便な一般合成法を開発した。本法を用いて、ベルベリンを始め各種プロトベルベリンアルカロイドを合成した。2.プロトベルベリンからエナミン体を経由する、ベンゾフェナンスリジンの短工程による新しい生合成的合成法を開拓した。本法を用いて、ケレリスリンやニチジンなどのベンゾフェナンスリジンアルカロイドの全合成に成功した。3.パラジウム触媒を用いた ...
Hanaoka Miyoji, 花岡 美代次
core   +1 more source

Phytochemicals are the promising tools towards drug-resistant cancers [PDF]

open access: yes, 2016
Cancer cells rapidly acquire drug (single/multi) resistance. In this regard, continuous efforts are necessary to better understand the drug resistance mechanisms along with or aiming to boost of discovery of sufficient and new anticancer drugs.
Islam, Muhammad Torequl   +1 more
core   +1 more source

6-Methoxydihydroavicine is a benzophenanthridine alkaloid with anti-leukemia activity

open access: yesFrontiers in Pharmacology
BackgroundAcute myeloid leukemia (AML) is an aggressive hematological malignancy with limited therapeutic options. Despite recent advances in targeted therapies, patients are still faced with poor survival outcomes. Thus, development of novel therapeutic agents with broad efficacy remains an urgent need.MethodsWe conducted a natural compound library ...
Yingying Yang, Paul A. Spagnuolo
openaire   +3 more sources

Phytochemical variations within populations of Platycapnos saxicola Willk [PDF]

open access: yes, 2004
The amounts of sinoacutine, glaucine and protopine were used to identify three phytochemical groups from the six known populations of Platycapnos saxicola Willk. A combination of GC/MS and 1 H-NMR have been used for the identification and quantitation of
Ana Cuevas   +5 more
core  

Phytochemical studies on certain South African species of the rutaceous genera Agathosma Willd. and Zanthoxylum L [PDF]

open access: yes, 1979
Selected species of two South African rutaceous genera, Agathosma Willd. and Zanthoxylum L., were phytochemically studied. Two species of the former genus, A. puberula (Steud.) Fourc . and A. elavisepala R. A.
Finkelstein, Nathan
core   +1 more source

PLANT PROFILE, PHYTOCHEMISTRY AND PHARMACOLOGY OF ARGEMONE MEXICANA LINN.A REVIEW [PDF]

open access: yes, 2014
Argemonemexicanais extensively used as traditional medicine for the treatment of numerous diseases. Various parts of the plant were extensively used in Ayurveda, Siddha, Unani and Homeopathic medicines.It is reported to have antimicrobial activity, wound
G. M., Vidyasagar, Sharanappa, Rekha
core   +1 more source

The Role of the Iminium Bond in the Inhibition of Reverse Transcriptase by Quaternary Benzophenanthridines

open access: yesJournal of Pharmacy and Pharmacology, 1998
AbstractThe quaternary benzo[c]phenanthridines fagaronine, nitidine and O-methylfagaronine have been reviewed as potential antitumour and antiviral agents. Their mode of action has not been established, but their ability to bind with DNA by intercalation is believed to be involved.Of the three synthetic analogues of O-methylfagaronine which we have ...
M A, Kerry   +3 more
openaire   +2 more sources

Palladium-katalysierte Funktionalisierung und Zyklisierung sowie Säure-vermittelte Zykloisomerisierung von Chinolin-Derivaten [PDF]

open access: yes
Die Arbeit befasst sich mit der Palladium-katalysierten sowie der Brønsted-Säure-vermittelten Zyklisierung von Chinolinen. Die Indolochinoline konnten durch eine Palladium-katalysierte Suzuki-Miyaura-Reaktion, gefolgt von einer Buchwald-Hartwig ...
Janke, Sophie (gnd: 1200998308)
core   +1 more source

Bioactive alkaloids from medicinal plants of Bhutan [PDF]

open access: yes, 2004
Natural products had been indispensably used by many cultures and traditions in folklore medicines for thousands of years. These traditional medicines cater to about 85% of the world population for their primary health care needs.
Wangchuk, Phurpa
core   +1 more source

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