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A new intermolecular benzyne cycloaddition approach to benzophenanthridines
Tetrahedron Letters, 1990Abstract The Intermolecular Benzyne Cycloaddition (IBC) approach was used for the synthesis of benzophenanthridines by constructing ring C in the key cycloaddition ...
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Structural insights into the benzophenanthridines binding to human glycine transporter GlyT1
European Journal of Pharmacology, 2015We previously identified cysteine 475 as a key residue for the inhibitory action of sanguinarine on the human glycine transporter GlyT1c. To define potential benzophenanthridine binding pocket more closely, we created a structural homology model of GlyT1 and also mutated several amino acids in the vicinity of cysteine 475.
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