Results 101 to 110 of about 494 (132)

Molecular targets and anticancer potential of sanguinarine—a benzophenanthridine alkaloid

Phytomedicine, 2017
Cancer is an enormous global health burden, and should be effectively addressed with better therapeutic strategies. Currently, over 60% of the clinically approved anticancer agents are either directly isolated from natural sources or are modified from natural lead molecules.
Sehamuddin, Galadari, Anees, Rahman, Siraj, Pallichankandy, Faisal, Thayyullathil   +3 more
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Isochelidonine, a benzophenanthridine alkaloid from chelidonium majus

Phytochemistry, 1992
Abstract A new benzophenanthridine alkaloid, isochelidonine, has been isolated from Chelidonium majus and characterized mainly by spectral analysis. Isochelidonine is the first benzophenanthridine alkaloid from the Papaveraceae with C-10,11 substituents.
Salvatore De Rosa, Giuseppe Di Vincenzo
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Inhibition of Reverse Transcriptase Activity by Benzophenanthridine Alkaloids

Journal of Natural Products, 1979
Benzophenanthridine alkaloids, fagaronine 4, O-methylfagaronine 5, nitidine 1, allonitidine 3 and methoxydihydronitidine 2 have been shown to posses inhibitory activity against reverse transcriptase of RNA tumor viruses. The enzyme inhibition (50%) by these alkaloids was found in the range of 6-60 microgram per milliliter of the reaction mixture when ...
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Identification of metabolites of selected benzophenanthridine alkaloids and their toxicity evaluation

Journal of Pharmaceutical and Biomedical Analysis, 2016
Selected benzo[c]phenathridine alkaloids were biotransformed using rat liver microsomes and identified by liquid chromatography and mass spectrometry. While the metabolites of commercially available sanguinarine and chelerythrine have been studied in detail, data about the metabolism of the minor alkaloids remained unknown.
Roman, Sandor, Adam, Midlik, Kristyna, Sebrlova, Gabriela, Dovrtelova, Kristyna, Noskova, Jan, Jurica, Iva, Slaninova, Eva, Taborska, Ondrej, Pes   +8 more
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A New Benzophenanthridine Alkaloid from Zanthoxylum nitidum

Chinese Journal of Natural Medicines, 2009
Abstract Aim To study the chemical constituents of the roots and stems of Zanthoxylum nitidum (Roxb.) DC.. Methods Silica gel and Sephadex LH-20 column chromatography were used to isolate and purify the constituents. Various spectroscopic analyses were involved to elucidate the structures.
Di GENG, Ding-Xiang LI, Yao SHI, Jing-Yu LIANG, Zhi-Da MIN   +4 more
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Reduction of quaternary benzophenanthridine alkaloids by NADH and NADPH

Collection of Czechoslovak Chemical Communications, 1986
Spectroscopic techniques have shown that quaternary benzophenanthridine alkaloids (sanguinarine (Ia), chelerythrine (Ie), sanguilutine (If), sanguirubine (Ic), chelirubine (Ib), and chelilutine (Id)) are reduced by NADH or NADPH to their dihydro forms. The formation of the oxidized form of a coenzyme was demonstrated by HPLC.
Jan Kovář, Jaromír Stejskal, Hana Paulová, Jiří Slavík   +3 more
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Sequence‐selective, pH‐dependent binding to DNA of benzophenanthridine alkaloids

Journal of Molecular Recognition, 1990
AbstractThe sequence selectivity associated with binding to DNA of three alkaloids belonging to the benzophenanthridine family has been analysed by DNase I footprinting, and the results were compared with those obtained from an analysis of the behaviour of the standard intercalator, ethidium bromide.
N P, Bajaj, M J, McLean, M J, Waring, E, Smekal   +3 more
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Inhibition of liver alanine aminotransferase activity by some benzophenanthridine alkaloids

Journal of Medicinal Chemistry, 1981
The quaternary benzophenanthridine alkaloids sanguinarine (1) and chelerythrine (2) inhibit rat liver L-alanine-:2-oxoglutarate aminotransferase (EC 2.6.1.2) activity. Nitidine (3) has no inhibitory effect. The inhibitory activity of alkaloids depends on the reactivity of the iminium bond with the nucleophilic reagent, e.g., the thiol group.
D, Walterová, , Ulrichová, V, Preininger, V, Simánek, J, Lenfeld, J, Lasovský   +5 more
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Micelle assisted structural conversion with fluorescence modulation of benzophenanthridine alkaloids

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2017
In this study we have reported the anionic surfactant (Sodium dodecyl sulfate, SDS) driven structural conversion of two benzophenanthridine plant alkaloids namely Chelerythrine (herein after CHL) and Sanguinarine (herein after SANG). Both the alkaloids exist in two forms: the charged iminium and the neutral alkanolamine form. The iminium form is stable
Ankur Bikash, Pradhan, Sutanwi, Bhuiya, Lucy, Haque, Richa, Tiwari, Suman, Das   +4 more
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Vasorelaxant and tracheorelaxant effects of Bocconia arborea and their isolated benzophenanthridine alkaloids

Fitoterapia
Bocconia arborea S. Watson (Papaveraceae) is an abundant medicinal plant in the North of Morelos State, Mexico, which is used for the treatment of several diseases. The aim of current investigation was to isolate the compounds responsible of the relaxant effect shown by the active extracts.
Emmanuel, Gaona-Tovar, Samuel, Estrada-Soto, Armando, Ramírez-Hernández, Luis, Arias-Durán, Hugo, Tlahuext, Rafael, Villalobos-Molina, Julio C, Almanza-Pérez   +6 more
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