Results 221 to 230 of about 8,683,971 (293)

Standardized Spectral Mapping With ¹²⁹Xe Chemical Shift Imaging: Investigating Red Blood Cell Shift Heterogeneity in Pulmonary Hypertension. [PDF]

NMR Biomed
Costelle A, Leewiwatwong S, Mugler JP, Mummy D, Rajagopal S, Driehuys B.   +5 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Comparative Characterization of Phytochemicals and In Vivo Metabolites of Aqueous and Ethanol Extracts of Callicarpa nudiflora by UHPLC-Q-TOF-MS/MS and Molecular Networking Combined Multivariate Statistical Methods. [PDF]

Biomed Chromatogr
Chen Y, Mei YQ, Su XY, Hou J, Li KJ, Hou L.   +5 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Resolving aromatic spectral congestion in whole-cell solid-state NMR: Signatures of condensed tannins and lignin in plant tissues. [PDF]

Cell Surf
Sahu P, Xiao P, Debnath D, Yarava JR, Cheng Q, Wang T.   +5 more
europepmc   +1 more source

Chemical Warfare—A Chemical and Toxicological Review

American Journal of Public Health and the Nations Health, 1944
openaire   +3 more sources