Results 161 to 170 of about 226,393 (319)

Figuring Out Gas and Galaxies In Enzo (FOGGIE). VIII. Complex and Stochastic Metallicity Gradients at z > 2

The Astrophysical Journal
Gas-phase metallicity gradients are a crucial element in understanding the chemical evolution of galaxies. We use the FOGGIE simulations to study the metallicity gradients (∇ Z ) of six Milky Way–like galaxies throughout their evolution.
Ayan Acharyya, Molly S. Peeples, Jason Tumlinson, Brian W. O’Shea, Cassandra Lochhaas, Anna C. Wright, Raymond C. Simons, Ramona Augustin, Britton D. Smith, Eugene Hyeonmin Lee   +9 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Modeling the Ages and Chemical Abundances of Elliptical Galaxies

The Astrophysical Journal
Spectroscopic studies of elliptical galaxies show that their stellar population ages, mean metallicity, and α enhancement traced by [Mg/Fe] all increase with galaxy stellar mass or velocity dispersion.
Nicole Marcelina Gountanis, David H. Weinberg, Aliza G. Beverage, Nathan R. Sandford, Charlie Conroy, Mariska Kriek   +5 more
doaj   +1 more source

Chemical abundances of the metal-poor horizontal-branch stars CS 22186-005 and CS 30344-033 [PDF]

, 2014
Şeyma Çalışkan, E. Caffau, P. Bonifacio, N. Christlieb, L. Monaco, Timothy C. Beers, B. Albayrak, L. Sbordone   +7 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Under Pressure: Decoding the Effect of High Densities on Derived Nebular Properties

The Astrophysical Journal
Recent JWST observations have uncovered a population of compact, high-redshift ( z  > 6) galaxies exhibiting extreme nebular conditions and enhanced nitrogen abundances that challenge standard chemical evolution paradigms.
Zorayda Martinez, Danielle A. Berg, Bethan L. James, Karla Z. Arellano-Córdova, Daniel P. Stark, Peter Senchyna, Evan D. Skillman, Noah S. J. Rogers, John Chisholm   +8 more
doaj   +1 more source

Chemical abundances in metal-poor giants: limitations imposed by the use of classical 1D stellar atmosphere models [PDF]

, 2011
V. Dobrovolskas, A. Kučinskas, H.‐G. Ludwig, E. Caffau, J. Klevas, D. Prakapavičius   +5 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Determining Stellar Elemental Abundances from DESI Spectra with the Data-driven Payne

The Astrophysical Journal Supplement Series
Stellar abundances for a large number of stars provide key information for the study of Galactic formation history. Large spectroscopic surveys such as the Dark Energy Spectroscopic Instrument (DESI) and LAMOST take median-to-low-resolution ( R ≲ 5000 ...
Meng Zhang, Maosheng Xiang, Yuan-Sen Ting, Jiahui Wang, Haining Li, Hu Zou, Jundan Nie, Lanya Mou, Tianmin Wu, Yaqian Wu, Jifeng Liu   +10 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source