Results 141 to 150 of about 84,685 (303)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Complete Survey of r-process Conditions: The (Un)robustness of the r-process(es)
The Astrophysical JournalHeavy elements are synthesized by the r -process in neutron star mergers and potentially in rare supernovae linked to strong magnetic fields. Expensive hydrodynamic simulations of these extreme environments are usually postprocessed to calculate the ...
Jan Kuske +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
The First Chemical Census of the Milky Way’s Nuclear Star Cluster
The Astrophysical Journal LettersAn important step in understanding the formation and evolution of the nuclear star cluster (NSC) is to investigate its chemistry and chemical evolution. Additionally, exploring the NSC’s relationship to the other structures in the Galactic center and the
Govind Nandakumar +6 more
doaj +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Tracking the Chemical Evolution of Hydrocarbons Through Carbon Grain Supply in Protoplanetary Disks
The Astrophysical JournalThe gas present in planet-forming disks typically exhibits strong emission features of abundant carbon and oxygen molecular carriers. In some instances, protoplanetary disks show an elevated C/O ratio above interstellar values, which leads to a rich ...
Eshan Raul +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
What Can We Learn from the Nitrogen Abundance of High-z Galaxies?
The Astrophysical JournalWe present measurements of the gas-phase oxygen and nitrogen abundances obtained by applying the direct method to JWST NIRspec R ∼ 1000 spectroscopy for six galaxies at redshift greater than 3.
Massimo Stiavelli +11 more
doaj +1 more source
FEBS Open Bio, EarlyView.Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley +1 more source
The OCCASO Survey: Open Clusters Chemical Abundances from Spanish Observatories
, 2015 Stellar clusters are crucial in the study of a variety of topics including the star formation process, stellar nucleosynthesis and evolution, dynamical interaction among stars, or the assembly and evolution of galaxies. In particular, Open Clusters (OCs)
C. Jordi +3 more
core +1 more source