Results 131 to 140 of about 5,445,983 (296)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Chemical Literature

, 1962
Quarterly supplement for "the regular journals of the American Chemical Society," containing annotated bibliographies of chemical documentation literature as well as information about meetings, conferences, awards, scholarships, and other news from the ...
American Chemical Society. Division of Chemical Literature., Valeri, Virginia   +1 more
core   +1 more source

The Impact of Initial Composition on Massive Star Evolution and Nucleosynthesis

The Astrophysical Journal
We study the sensitivity of presupernova evolution and supernova nucleosynthesis yields of massive stars to variations of the initial composition. We use the solar abundances from Lodders, and compute two different sets of initial stellar compositions ...
Christopher West, Alexander Heger, Benoit Côté, Lev Serxner, Haoxuan Sun   +4 more
doaj   +1 more source

Gaia FGK benchmark stars: Spectral library and abundances of α and Fe-peak elements of the third version

Astronomy & Astrophysics
Context. Accurate determination of the chemical abundances in stars plays a pivotal role in understanding stellar structure and evolution, nucleosynthesis, and the chemical enrichment history of the Milky Way.
Casamiquela L., Soubiran C., Jofré P., Vitali S., Blanco-Cuaresma S., Lagarde N., Slumstrup D., Heiter U., Palmerio J. T., Brouillet N., Elgueta S., Rojas–Arriagada A., Aguilera–Gómez C., Hernández–Araya I., Creevey O. L., Balaguer–Núñez L., Carrera R.   +16 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Chemical Literature

, 1965
Quarterly supplement for "the regular journals of the American Chemical Society," containing annotated bibliographies of chemical documentation literature as well as information about meetings, conferences, awards, scholarships, and other news from the ...
American Chemical Society. Division of Chemical Literature., Cortelyou, Ethaline   +1 more
core   +1 more source

Noble Gas Planetology and the Xenon Clouds of Uranus

The Planetary Science Journal
Noble gases provide tracers of cosmic provenance that are accessible to a future Uranus atmospheric probe. Argon and krypton are expected to be well mixed on Uranus with respect to H _2 and He, although condensation at the winter pole may be possible ...
Kevin Zahnle
doaj   +1 more source

Chemical Literature

, 1966
Quarterly supplement for "the regular journals of the American Chemical Society," containing annotated bibliographies of chemical documentation literature as well as information about meetings, conferences, awards, scholarships, and other news from the ...
American Chemical Society. Division of Chemical Literature., Cortelyou, Ethaline   +1 more
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source