Results 111 to 120 of about 5,855,365 (255)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The GALAH survey: Improving chemical abundances using star clusters

Large spectroscopic surveys aim to consistently compute stellar parameters of very diverse stars, while minimizing systematic errors. We explore the use of stellar clusters as benchmarks to verify the precision of spectroscopic parameters in the fourth ...
Buder, Sven, Beeson, Kevin L., Daniel B. Zucker, Freeman, Ken, Gayandhi M. De Silva, Bland-Hawthorn, Joss, Kevin L. Beeson, Gary S. Da Costa, D'Orazi, Valentina, Dennis Stello, Madeline Howell, Zwitter, Tomaz, Michael Hayden, Tomaž Zwitter, Traven, Gregor, Sharma, Sanjib, Thomas Nordlander, Sven Buder, Nordlander, Thomas, Janez Kos, Sarah L. Martell, Zucker, Daniel B., Ken Freeman, De Grijs, Richard, Stello, Dennis, Da Costa, Gary S., De Silva, Gayandhi M., Siddhartha Saikia, Lind, Karin, Kos, Janez, Joss Bland-Hawthorn, Karin Lind, Martell, Sarah L., McKenzie, Madeleine, Richard de Grijs, Madeleine McKenzie, Gregor Traven, Hayden, Michael, Sanjib Sharma, Howell, Madeline, Geraint F. Lewis, Lewis, Geraint F., Valentina D’Orazi, Saikia, Siddhartha, D’Orazi, Valentina, Howell, Madeline,, Sharma, Sanjib,, Beeson, Kevin L.,, Lind, Karin,, Beeson, Kevin Luke, Lewis, Geraint F.,, Freeman, Ken,, De Silva, Gayandhi M.,, D'Orazi, Valentina,, Martell, Sarah L.,, Zwitter, Tomaz,, Kos, Janez,, Stello, Dennis,, Nordlander, Thomas,, De Grijs, Richard,, Saikia, Siddhartha,, Bland-Hawthorn, Joss,, Da Costa, Gary S.,, Buder, Sven,, Hayden, Michael,, Traven, Gregor,, McKenzie, Madeleine,, Zucker, Daniel B.,   +67 more
core   +1 more source

Noble Gas Planetology and the Xenon Clouds of Uranus

The Planetary Science Journal
Noble gases provide tracers of cosmic provenance that are accessible to a future Uranus atmospheric probe. Argon and krypton are expected to be well mixed on Uranus with respect to H _2 and He, although condensation at the winter pole may be possible ...
Kevin Zahnle
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Abundances in the Galactic Disk

, 2002
I will constrain myself to discussion of abundances and abundance gradients in the local Galactic Disk and continue with the scatter in these abundances, presently and historically.
Edvardsson, Bengt,
core   +3 more sources

The Impact of Initial Composition on Massive Star Evolution and Nucleosynthesis

The Astrophysical Journal
We study the sensitivity of presupernova evolution and supernova nucleosynthesis yields of massive stars to variations of the initial composition. We use the solar abundances from Lodders, and compute two different sets of initial stellar compositions ...
Christopher West, Alexander Heger, Benoit Côté, Lev Serxner, Haoxuan Sun   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

New Neutral–Neutral Pathways in the Chemistry of Silicon- and Sulfur-bearing Molecules in the Cold Interstellar Medium

The Astrophysical Journal
Silicon is the most abundant third-row element in space and plays a major role in interstellar dust as silicate particles. Furthermore, silicon is important for the formation of silicate dust in oxygen-rich AGB stars and in supernova remnants.
Samuel F. M. Costa, Márcio O. Alves, Sérgio Pilling, Jing Li, Breno R. L. Galvão   +4 more
doaj   +1 more source