Results 111 to 120 of about 84,685 (303)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Element Nucleosynthetic Origins from Abundance Spatial Distributions beyond the Milky Way

The Astrophysical Journal Letters
An element’s astrophysical origin should be reflected in the spatial distribution of its abundance, yielding measurably different spatial distributions for elements with different nucleosynthetic sites.
Zefeng Li, Mark R. Krumholz, Anna F. McLeod, A. Mark Swinbank, Emily Wisnioski, J. Trevor Mendel, Francesco Belfiore, Giovanni Cresci, Giacomo Venturi, Jia-Lai Kang   +9 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Chemical Abundances of Local Group Globular Clusters

, 2014
Detailed chemical abundances of globular clusters in the Milky Way and M31 (the Andromeda Galaxy) are presented based on analyses of high resolution spectra.
Sakari, Charli
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Chemical abundances and chemical evolution of the Magellanic Clouds: Prospects for the future [PDF]

Symposium - International Astronomical Union, 1991
The prospects for future advances in understanding the chemical evolution of the Magellanic Clouds is reviewed on the basis of results presented at IAU Symposium #148. These are divided into three areas, the metallicity - age relationships, the current abundance set, and the theory of the chemical evolution of the Clouds.
openaire   +1 more source

The High-Redshift Gas-Phase Mass–Metallicity Relation in FIRE-2

The Astrophysical Journal Letters
The unprecedented infrared spectroscopic capabilities of JWST have provided high-quality interstellar medium metallicity measurements and enabled characterization of the gas-phase mass–metallicity relation (MZR) for galaxies at z ≳ 5 for the first time ...
Andrew Marszewski, Guochao Sun, Claude-André Faucher-Giguère, Christopher C. Hayward, Robert Feldmann   +4 more
doaj   +1 more source

THE CHEMICAL ABUNDANCES OF ATMOSPHERES OF K GIANT STARS

Odessa Astronomical Publications, 2017
The abundances of 18 cool giant stars in Vicinity of Sun have been determinated. This determination was made by using the method of model atmospheres. It should be noted that almost all elements show discrepancies in abundances determined for absorption ...
N. S. Komarov, N. Yu. Basak, T. I. Gorbaneva, L. E. Kantsen   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source