Results 91 to 100 of about 5,855,365 (255)

Recalibration of the Hα Surface Brightness–Radius Relation for Planetary Nebulae Using Gaia DR3: New Distances and the Milky Way Oxygen Radial Gradient

The Astrophysical Journal
The spatial distribution of chemical elements in the Galactic disk provides key constraints on models of galaxy evolution. However, studies using planetary nebulae (PNe) as tracers have been historically limited by large uncertainties in their distances.
Oscar Cavichia, Hektor Monteiro, Miguel Cerviño, Adalberto R. da Cunha-Silva, Walter J. Maciel, André F. S. Cardoso   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Chemical abundances of damped Ly

, 2002
A new method is presented for recovering the abundances of Damped Ly α systems (DLAs) taking into account the effects of dust depletion. For the first time, possible variations of the chemical composition of the dust are taken into account in ...
G. Vladilo
core   +1 more source

The Actinide-boost Star LAMOST J122216.85–063345.2: A Detailed r-process Abundance Study with Gemini-S/GHOST

The Astrophysical Journal
We present a detailed chemical-abundance analysis of an actinide-boost ( $\mathrm{log}\epsilon $ (Th/Dy) = –0.74) star, LAMOST J122216.85–063345.2 (J1222), a very metal-poor ([Fe/H] = –2.45) halo star with moderate enhancement in rapid neutron-capture ...
Miji Jeong, Young Sun Lee, Vinicius M. Placco, Yutaka Hirai, Timothy C. Beers, Jeong-Eun Heo, Kristin Chiboucas, Emily Deibert, Roberto Gamen, Venu M. Kalari, Eder Martioli, Ruben Diaz, Manuel Gomez- Jimenez, Roque Ruiz-Carmona, Greg Burley, J. Gordon Robertson, Kathleen Labrie, Joanna Thomas-Osip   +17 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Chemical abundances across the first kpc of the LMC

, 2019
The chemical evolution of the Large Magellanic Cloud (LMC) yields information on many different aspects of low-mass disc galaxy evolution, and the evolution of an interacting system.
Van der Swaelmen, Mathieu (8343477), Van der Swaelmen, Mathieu   +1 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Rapid Chemical Enrichment by Intermittent Star Formation in GN-z11

The Astrophysical Journal Letters
We interpret the peculiar supersolar nitrogen abundance recently reported by the James Webb Space Telescope observations for GN-z11 ( z = 10.6) using our state-of-the-art chemical evolution models.
Chiaki Kobayashi, Andrea Ferrara
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Determination of Abundances of Chemical Elements in Open Star Clusters of the Galaxy

Open Astronomy, 2016
Spectroscopic determinations of the relative abundances of chemical elements produced in different nuclear-synthesis processes, [el/Fe], are collected for 90 open star clusters of the Galaxy using data from 109 papers published between 1991 and 2015 ...
Gozha M. L., Koval’ V. V., Marsakov V. A.   +2 more
doaj   +1 more source