Results 91 to 100 of about 71,748 (265)

The High-Redshift Gas-Phase Mass–Metallicity Relation in FIRE-2

The Astrophysical Journal Letters
The unprecedented infrared spectroscopic capabilities of JWST have provided high-quality interstellar medium metallicity measurements and enabled characterization of the gas-phase mass–metallicity relation (MZR) for galaxies at z ≳ 5 for the first time ...
Andrew Marszewski, Guochao Sun, Claude-André Faucher-Giguère, Christopher C. Hayward, Robert Feldmann   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Recalibration of the Hα Surface Brightness–Radius Relation for Planetary Nebulae Using Gaia DR3: New Distances and the Milky Way Oxygen Radial Gradient

The Astrophysical Journal
The spatial distribution of chemical elements in the Galactic disk provides key constraints on models of galaxy evolution. However, studies using planetary nebulae (PNe) as tracers have been historically limited by large uncertainties in their distances.
Oscar Cavichia, Hektor Monteiro, Miguel Cerviño, Adalberto R. da Cunha-Silva, Walter J. Maciel, André F. S. Cardoso   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Actinide-boost Star LAMOST J122216.85–063345.2: A Detailed r-process Abundance Study with Gemini-S/GHOST

The Astrophysical Journal
We present a detailed chemical-abundance analysis of an actinide-boost ( $\mathrm{log}\epsilon $ (Th/Dy) = –0.74) star, LAMOST J122216.85–063345.2 (J1222), a very metal-poor ([Fe/H] = –2.45) halo star with moderate enhancement in rapid neutron-capture ...
Miji Jeong, Young Sun Lee, Vinicius M. Placco, Yutaka Hirai, Timothy C. Beers, Jeong-Eun Heo, Kristin Chiboucas, Emily Deibert, Roberto Gamen, Venu M. Kalari, Eder Martioli, Ruben Diaz, Manuel Gomez- Jimenez, Roque Ruiz-Carmona, Greg Burley, J. Gordon Robertson, Kathleen Labrie, Joanna Thomas-Osip   +17 more
doaj   +1 more source

Determination of Abundances of Chemical Elements in Open Star Clusters of the Galaxy

Open Astronomy, 2016
Spectroscopic determinations of the relative abundances of chemical elements produced in different nuclear-synthesis processes, [el/Fe], are collected for 90 open star clusters of the Galaxy using data from 109 papers published between 1991 and 2015 ...
Gozha M. L., Koval’ V. V., Marsakov V. A.   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Rapid Chemical Enrichment by Intermittent Star Formation in GN-z11

The Astrophysical Journal Letters
We interpret the peculiar supersolar nitrogen abundance recently reported by the James Webb Space Telescope observations for GN-z11 ( z = 10.6) using our state-of-the-art chemical evolution models.
Chiaki Kobayashi, Andrea Ferrara
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source