Results 101 to 110 of about 5,855,365 (255)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Chemical Doppelgangers in GALAH DR3: The Distinguishing Power of Neutron-capture Elements among Milky Way Disk Stars

The Astrophysical Journal
The observed chemical diversity of Milky Way stars places important constraints on Galactic chemical evolution and the mixing processes that operate within the interstellar medium. Recent works have found that the chemical diversity of disk stars is low.
Catherine Manea, Keith Hawkins, Melissa K. Ness, Sven Buder, Sarah L. Martell, Daniel B. Zucker   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Chemical abundances of planetary nebulae towards the Galactic anticenter

, 2004
In this paper we report new observations and derive chemical abundances for a sample of 26 planetary nebulae (PN) located in the anticenter direction. Most of these nebulae are far away objects, located at Galactocentric distances greater than about 8 ...
W. J. Maciel, R. D. D. Costa, M. M. M. Uchida   +2 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

The Open Cluster Chemical Abundances and Mapping Survey. IX. Measuring the Effects of Stellar Diffusion in the Open Clusters NGC 752 and Ruprecht 147 Using APOGEE

The Astrophysical Journal
A growing understanding of stellar processes that alter surface chemical abundances over time has opened new avenues for using these changes as probes of stellar properties.
Diogo Souto, Taylor Spoo, Peter M. Frinchaboy, Katia Cunha, Jamie Tayar, Alessa Ibrahim Wiggins, Natalie Myers   +6 more
doaj   +1 more source

Gaia FGK benchmark stars: Spectral library and abundances of α and Fe-peak elements of the third version

Astronomy & Astrophysics
Context. Accurate determination of the chemical abundances in stars plays a pivotal role in understanding stellar structure and evolution, nucleosynthesis, and the chemical enrichment history of the Milky Way.
Casamiquela L., Soubiran C., Jofré P., Vitali S., Blanco-Cuaresma S., Lagarde N., Slumstrup D., Heiter U., Palmerio J. T., Brouillet N., Elgueta S., Rojas–Arriagada A., Aguilera–Gómez C., Hernández–Araya I., Creevey O. L., Balaguer–Núñez L., Carrera R.   +16 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Uncertainties in Atomic Data and How They Propagate in Chemical Abundances Atomic Data for Astrophysics

, 2020
. Some recent calculations of basic atomic data which are of importance for astrophysical applications are briefly reviewed. A few issues concerning the derivation of chemical abundances from remote-sensing XUV measurements are then ...
G Del Zanna, V Luridiana, J García Rojas, A Manchado   +3 more
core  

Evolved Stars with Inconsistent Age Estimates: Abundance Outliers or Mass Transfer Products?

The Astrophysical Journal
In the Milky Way disk, there is a strong trend linking stellar age to surface element abundances. Here, we explore this relationship with a data set of 8803 red-giant and red-clump stars with both asteroseismic data from NASA Kepler Mission and surface ...
Polly Frazer, Emily J. Griffith, David W. Hogg, Amaya Sinha, Jamie Tayar   +4 more
doaj   +1 more source