Results 211 to 220 of about 4,406,721 (399)

TEMPLATES: Direct Abundance Constraints for Two Lensed Lyman-break Galaxies

The Astrophysical Journal
Using integrated spectra for two gravitationally lensed galaxies from the JWST TEMPLATES Early Release Science program, we analyze faint auroral lines, which provide direct measurements of the gas-phase chemical abundance.
Brian Welch, Grace M. Olivier, Taylor A. Hutchison, Jane R. Rigby, Danielle A. Berg, Manuel Aravena, Matthew B. Bayliss, Jack E. Birkin, Scott C. Chapman, Håkon Dahle, Michael D. Gladders, Gourav Khullar, Keunho J. Kim, Guillaume Mahler, Matthew A. Malkan, Desika Narayanan, Kedar A. Phadke, Keren Sharon, J. D. T. Smith, Manuel Solimano, Justin S. Spilker, Joaquin D. Vieira, David Vizgan   +22 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

On the Chemical Abundances of Multiple‐Shell Planetary Nebulae with Halos [PDF]

, 1999
M. A. Guerrero, A. Manchado
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Mixed Source Region Signatures inside Magnetic Switchback Patches Inferred by Heavy Ion Diagnostics

The Astrophysical Journal
Since Parker Solar Probe’s (Parker’s) first perihelion pass at the Sun, large-amplitude Alfvén waves grouped in patches have been observed near the Sun throughout the mission.
Yeimy J. Rivera, Samuel T. Badman, Michael L. Stevens, Jim M. Raines, Christopher J. Owen, Kristoff Paulson, Tatiana Niembro, Stefano A. Livi, Susan T. Lepri, Enrico Landi, Jasper S. Halekas, Tamar Ervin, Ryan M. Dewey, Jesse T. Coburn, Stuart D. Bale, B. L. Alterman   +15 more
doaj   +1 more source

Abundance of the chemical elements in man's diet and possible relations with environmental factors

, 1973
E.I. Hamilton, M.J. Minski
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Simulating Chemical Abundances in the Circumstellar Nebula of the Late Stage Binary RY Scuti

The Astronomical Journal
RY Scuti, thought to be a Wolf–Rayet (WR) progenitor, is a massive post-main-sequence binary star system undergoing Roche-lobe overflow (RLOF). SOFIA (+FORCAST) spectroscopy of the inner, ionized region of RY Scuti’s double ringed toroidal nebula affirms
Sarah H. Taft, Robert D. Gehrz, Charles E. Woodward, Nathan Smith, Isabelle Perron, Annalisa Citro   +5 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source