Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Abundance of microplastics and nanoplastics in urban atmosphere. [PDF]
Hu T +17 more
europepmc +1 more source
A determination of the thick disk chemical abundance distribution: Implications for galaxy evolution [PDF]
Gerard Gilmore +2 more
openalex +1 more source
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Gene-Level Shift in Response to Synthetic Nitrogen Addition Promotes <i>Larix olgensis</i> (Ussurian Larch) Growth in a Short-Term Field Trial. [PDF]
Ameer MJ, Liu Y, Yan S, Qu T.
europepmc +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Temporal and spatial dynamics of microbial communities and greenhouse gas flux responses to experimental flooding in riparian forest soils. [PDF]
Reiss K +11 more
europepmc +1 more source
Density Distribution and Chemical Abundances in NGC 7027 [PDF]
Andrea Preite-Martinez, Nino Panagiat
openalex +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Prospects for detecting signs of life on exoplanets in the JWST era. [PDF]
Seager S +4 more
europepmc +1 more source

