Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Modeling the Ages and Chemical Abundances of Elliptical Galaxies
The Astrophysical JournalSpectroscopic studies of elliptical galaxies show that their stellar population ages, mean metallicity, and α enhancement traced by [Mg/Fe] all increase with galaxy stellar mass or velocity dispersion.
Nicole Marcelina Gountanis +5 more
doaj +1 more source
Chemical abundance gradients of organic molecules within a protostellar disk [PDF]
Levi G. Walls +2 more
openalex +1 more source
About compiled catalogue of spectroscopic determined chemical abundances for stars with accurate parallaxes. Magnesium [PDF]
, 2005 T. V. Borkova, В. А. Марсаков
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
A Photoionization Model for the Infrared Coronal Line Emission in the Classical Nova V1716 Scorpii
The Astrophysical JournalA near-infrared spectrum of nova V1716 Scorpii (PNV J17224490-4137160), a recent bright ( ${V}_{\max }=7.3$ mag), Fermi-LAT detected γ -ray source, was modeled using the photoionization code CLOUDY.
C. E. Woodward +4 more
doaj +1 more source
On the Chemical Abundances of Miras in Clusters: V1 in the Metal-rich Globular NGC 5927* [PDF]
, 2018 V. D’Orazi +52 more
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Protein O‐glycosylation in the Bacteroidota phylum
FEBS Open Bio, EarlyView.Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns +2 more
wiley +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source