Results 171 to 180 of about 852,367 (264)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Elaboration of fibrous structured activated carbon from olive pomace via chemical activation and low-temperature pyrolysis. [PDF]

Heliyon
Alouiz I, Benhadj M, Dahmane E, Sennoune M, Amarouch MY, Mazouzi D.   +5 more
europepmc   +1 more source

Effect of Surface Treatment by O₃ and Chemical Activation by Alkali Metal on the Performance of ACFs on Adsorption and Desorption of BTX Gases. [PDF]

Int J Environ Res Public Health, 2020
Jang JH, Han GB.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4⁺ T cell for inflammatory bowel diseases treatment. [PDF]

Cell Rep Med
Zhang J, Jiang Y, Fan D, Qiu Z, He X, Liu S, Li L, Dai Z, Zhang L, Shu Z, Li L, Zhang H, Yang T, Luo Y.   +13 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Biomass-Based Activated Carbon and Activators: Preparation of Activated Carbon from Corncob by Chemical Activation with Biomass Pyrolysis Liquids. [PDF]

ACS Omega, 2020
Feng P, Li J, Wang H, Xu Z.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Chemical activation and magnetization of carbonaceous materials fabricated from waste plastics and their evaluation for methylene blue adsorption. [PDF]

Environ Sci Pollut Res Int
Salama E, Samy M, Hassan HS, Mohamed S, Mensah K, Elkady MF.   +5 more
europepmc   +1 more source

Preparation of Highly Porous Graphitic Activated Carbon as Electrode Materials for Supercapacitors by Hydrothermal Pretreatment-Assisted Chemical Activation. [PDF]

ACS Omega, 2020
Liu D, Xu B, Zhu J, Tang S, Xu F, Li S, Jia B, Chen G.   +7 more
europepmc   +1 more source