Results 51 to 60 of about 18,764,038 (293)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Heliyon, 2019 Nine novel {bis-4-[(3-alkyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-iminomethyl]-phenyl} [1,1′-biphenyl]-4,4′-disulfonates were synthesized and their structures were determined with spectral methods.
Murat Beytur +3 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
FIELD TRAILS TO IMPACT OF COLONOZATION WITH AM-FUNGI, N2-FIXERS AND POTASSIUM SOLUBLIZING BACTERIA ON ONION CROPS (Allium cepa) [PDF]
Journal of Agricultural Chemistry and Biotechnology, 2009 Two field experiments were conducted in a calcareous soil at El-Noubaria Research Station (ARC) during two successive seasons (2006 and 2007) to study the effect of biofertilizer inoculation with nitrogen fixing bacteria (Azospirillum lipoferum ...
Faten Mohamed +2 more
doaj +1 more source
Chemical-based enzymatic activity of SOD1 variants.
Chemical-based enzymatic activity of SOD1 variants.
Md Amin Hossain (10170815) +37 more
core +1 more source
Structure-activity relationship in phenothiazine antipsychotic drugs: Molecular orbital calculation, in silico molecular docking and physico-chemical parameters [PDF]
, 2018 1194-1202A series of antipsychotic phenothiazine drugs, whose results of clinical trials are known, have been subjected to all valence molecular orbital calculations using AM1 method.
Thakkar, Sampark S +2 more
core
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
CYTPOWER: IMPLEMENTATION OF CYTOTOXIC POWER CONCEPT IN PYTHON
Journal of Bioinformatics and Genomics, 2018 Currently existing methods and parameters are inadequate for representative and quanititative assessment of cytotoxic activity of chemical compounds.
Maksim Aleksandrovich Terpilovskii, Dr. +1 more
doaj +1 more source