Results 41 to 50 of about 709,715 (218)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Retinal Toxicity Induced by Chemical Agents. [PDF]

Int J Mol Sci, 2022
Souza Monteiro de Araújo D, Brito R, Pereira-Figueiredo D, Dos Santos-Rodrigues A, De Logu F, Nassini R, Zin A, Calaza KC.   +7 more
europepmc   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

More than tears: associations between exposure to chemical agents used by law enforcement and adverse reproductive health outcomes. [PDF]

Front Epidemiol, 2023
Hassan A, Ojanen-Goldsmith A, Hing AK, Mahoney M, Traxler S, Boraas CM.   +5 more
europepmc   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

The dangerous link between coal dust exposure and DNA damage: unraveling the role of some of the chemical agents and oxidative stress. [PDF]

Environ Geochem Health, 2023
Miranda-Guevara A, Muñoz-Acevedo A, Fiorillo-Moreno O, Acosta-Hoyos A, Pacheco-Londoño L, Quintana-Sosa M, De Moya Y, Dias J, de Souza GS, Martinez-Lopez W, Garcia ALH, da Silva J, Borges MS, Henriques JAP, León-Mejía G.   +14 more
europepmc   +1 more source

Formaldehyde as a Chemical Defence Agent of Fruiting Bodies of Mycena rosea and its Role in the Generation of the Alkaloid Mycenarubin C [PDF]

, 2020
Rieke Himstedt, Silke Wagner, Robert J. R. Jaeger, Michèle‐Laure Lieunang Watat, Jana Backenköhler, Zeljka Rupcic, Marc Stadler, Peter Spiteller   +7 more
openalex   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

An experimental study to measure oil recovery factor by chemical agents and carbon dioxide after waterflooding. [PDF]

Sci Rep, 2022
Yang G, Bai Y, Song Y, Metwally ASM, Mahmoud O.   +4 more
europepmc   +1 more source

Reduced Graphene Oxide E-Fabric Wearable Sensors for Chemical Warfare Agents

, 2022
Dongwon Ka, Jaeheon Lee, Kyeong Min Cho, Hyunjoo Choi, Heesoo Jung, Min‐Kun Kim, Keunhong Jeong, Youngho Jin   +7 more
openalex   +1 more source