Results 51 to 60 of about 185,932 (259)

Physical and Chemical Factors that Improve Epidermal Permeability Barrier Homeostasis [PDF]

, 2012
For terrestrial creatures, the water-impermeable barrier function of the skin is essential to maintain life in the face of environmental dryness. Stratum corneum, which plays a crucial role in the barrier function, is composed of two components, i.e., protein-rich nonviable cells and intercellular lipid domains.
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

PREPARATION AND CHARACTERIZATION OF STARCH BASED EDIBLE/ BIODEGRADABLE FILMS [PDF]

Journal of Food and Dairy Sciences, 2007
To prepare good starch-based films the optimum concentration of high amylose starch was 8%. The various factors affecting the formation of these films were studied by measuring the physical (thickness and surface density), chemical (moisture content and ...
Y. Moharram, H. El-Sayed, Manal Tawfik, E. Soliman   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Nephropathogenic infectious bronchitis virus can induce duodenum inflammation and barrier defect in Hy-Line brown chickens

Poultry Science
Nephropathogenic infectious bronchitis virus (NIBV) is a common virus in the poultry breeding industry. NIBV infection can cause damage to the kidneys, respiratory tract, and intestines of chickens, leading to clinical signs such as coughing, loose stool,
Chenlu Feng, Bingqing Zhang, Cheng Huang, Yan Shi, Xiaona Gao, Yufan Shen, Zhihua Lu, Ruoyun Tang, Qiurong Qi, Salma Mbarouk Omar, Guyue Li, Ping Liu, Gaofeng Cai, Xiaoquan Guo   +13 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Transdermal Drug Delivery Systems: Methods for Enhancing Skin Permeability and Their Evaluation

Pharmaceutics
Transdermal drug delivery (TDD) is an increasingly important non-invasive method for administering active pharmaceutical ingredients (APIs) through the skin barrier, offering advantages such as improved therapeutic efficacy and reduced systemic side ...
Elena O. Bakhrushina, Marina M. Shumkova, Yana V. Avdonina, Arsen A. Ananian, Mina Babazadeh, Ghazaleh Pouya, Viktoria V. Grikh, Irina M. Zubareva, Svetlana I. Kosenkova, Ivan I. Krasnyuk, Ivan I. Krasnyuk   +10 more
doaj   +1 more source

Evidence of “wired” drug-cell communication through micro-barrier well-array devices

AIP Advances, 2019
Treatments designed to intervene in conventional direct-drug-to-cell-binding communication have been hallmark approaches in designing new drug candidates.
Ching-Te Kuo, Hsinyu Lee, Si-Chen Lee
doaj   +1 more source