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Chemical space and biology [PDF]
Chemical space--which encompasses all possible small organic molecules, including those present in biological systems--is vast. So vast, in fact, that so far only a tiny fraction of it has been explored. Nevertheless, these explorations have greatly enhanced our understanding of biology, and have led to the development of many of today's drugs.
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Phorbols : Chemical Synthesis and Chemical Biology
The phorbol esters, such as phorbol 12- myristate 13-acetate (PMA), are known to be powerful tumor promoters and activators of protein kinase C (PKC). First discovered by Nishizuka et al., PKC is a phospholipid- and calcium-dependent serine/threonine kinase, phisiologically activated by 1,2-diacyl-sn-glycerol (DAG). PKC is also known to be an important
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ケミカルバイオロジーという化学と生命科学の融合した新しい学問領域が勃興しつつある.ケミカルバイオロジーでは,ケミカルライブラリーからハイスループットスクリーニングなどによって有用な化合物を発見し,それらを用いてケミカルジェネティクスなどの手法で生命現象を担う仕組みの解明を目指す.このようにアプローチの方向は少し異なっているが,研究に低分子化合物を使う点で,ケミカルバイオロジーと薬理学とは共通項を有する.
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Chemical biology approaches for revealing interorganelle lipid transport pathways. [PDF]
Cho YT, Baskin JM.
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Correction to "Pseudonatural Products for Chemical Biology and Drug Discovery". [PDF]
Greiner LC +7 more
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ENDONUCLEASE V: FROM TRANSCRIPTOME REGULATOR TO CHEMICAL BIOLOGY TOOL. [PDF]
Thota P +5 more
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Biocompatible Chemistry: A Plug-and-Play Toolbox for Chemical Biology Research. [PDF]
Lovato AR, Lin Z, Zheng Q.
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Stimulus-Responsive Perselenide, Thioselenide, and Selenosulfide Donors for Reactive Selenium Species Chemical Biology. [PDF]
Tripathi R +9 more
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