Results 251 to 260 of about 84,861 (295)

Chemical Carcinogenesis

New England Journal of Medicine, 1981
Emmanuel Farber, Farber Emmanuel
exaly   +3 more sources

Chemical carcinogenesis

Cancer, 1975
The field of chemical carcinogenesis is reviewed, with emphasis on three aspects: 1) environmental chemicals are a major cause of human cancer; 2) most chemical carcinogens require metabolic activation by mixed-function oxidases to electrophilic metabolites that form strong covalent chemical bonds with cellular macromolecules and thereby initiate the ...
Thomas H. Maugh, Jean L. Marx
openaire   +4 more sources

Mechanisms of chemical carcinogenesis

Cancer, 1981
Of the known carcinogenic agents (viruses, ultraviolet and ionizing radiations, and chemicals), chemicals appear to be of major importance in the induction of human cancers. The known chemical carcinogens include a wide range of structures. Their common feature is that their ultimate forms are electrophilic reactants; in most cases, these reactants ...
E C, Miller, J A, Miller
openaire   +2 more sources

Environmental and chemical carcinogenesis

Seminars in Cancer Biology, 2004
People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as ...
Gerald N, Wogan, Stephen S, Hecht, James S, Felton, Allan H, Conney, Lawrence A, Loeb   +4 more
openaire   +2 more sources

Apoptosis and Chemical Carcinogenesis

Risk Analysis, 1994
Long recognized as a normal component of organogenesis during development, apoptosis (programmed cell death) has recently been implicated in alterations of cell growth and differentiation. Tissue homeostasis is normally maintained by a balance between cell division and cell death, with apoptosis often functioning in complement to cell growth.
D S, Marsman, J C, Barrett
openaire   +2 more sources

Chemical Carcinogenesis in Fishes

2008
Among the industrialized nations of the world, the potential for causing human cancers has been a great concern in risk assessments of environmental pollutants for many years. In contrast, this concern has historically occupied a lower level of interest among those evaluating the risk of chemical hazards to wildlife, including fishes.
Jeanette Rotchell, M.R. Miller, D.E. Hinton, R.T. Di Giulio, G.K. Ostrander   +4 more
openaire   +2 more sources

Thresholds in Chemical Carcinogenesis

Regulatory Toxicology and Pharmacology, 1995
It is common practice to base carcinogenic risk assessment on the view that there is no threshold for chemical carcinogenesis. In this context, the threshold is defined as a dose below which no effects are observed. Analysis of epidemiological and experimental data on chemical carcinogenesis confirms that no thresholds have been demonstrated in human ...
I F, Purchase, T R, Auton
openaire   +2 more sources

Chemical Carcinogenesis

, 1988
Sardinian International Meeting on Modulating Factors in Multistage Chemical Carcinogenesis 1989 Cagliari, Columbano, Amedeo, Feo, Francesco   +2 more
openaire   +2 more sources

The pharmacogenetics of chemical carcinogenesis

Pharmacogenetics, 1992
The human body is endowed with a large number of xenobiotic chemical metabolizing enzymes, a significant proportion of which are polymorphic and thus render one individual at greater or lesser risk than another of chemically-induced disease. All examples of genetic polymorphism of chemical metabolizing enzymes have been reviewed in relation to their ...
Idle, J. R., Armstrong, M., Boddy, A. V., Boustead, C., Cholerton, S., Cooper, J., Daly, A. K., Ellis, Gregory, W., Hadidi, H., Hofer, Holt, Leathart, McCracken, N., Monkman, S. C., Painter, J. E., Taber, Walker, D., Yule   +31 more
openaire   +3 more sources