Results 141 to 150 of about 2,743,615 (301)
Archivos Latinoamericanos de NutriciónDe cada marca comercial se tomaron cuatro lotes distintos de producción, las muestras se adquirieron en los mercados de Maracay, Cagua y Turmero (Venezuela).
Ricardo López G. +2 more
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
On the chemical composition of L-chondrites [PDF]
Radiochemical neutron activation analysis of Ag, As, Au, Bi, Co, Cs, Ga, In, Rb, Sb, Te, Tl, and Zn and major element data in 14 L4-6 and 3 LL5 chondrites indicates that the L group is unusually variable and may represent at least 2 subgroups differing ...
Dodd, R. T. +3 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A new method to determine the chemical composition of the cosmic rays beyond 10 to the 15th power eV [PDF]
The chemical composition of primary cosmic rays beyond 10 to the 15th power eV could not be measured by the direct method. A more sensitive method to determine the chemical composition is proposed.
Muraki, Y.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Valorization of Olive Stones: Chemical Composition and Bioactivity. [PDF]
Pharmaceuticals (Basel)Nunes B +10 more
europepmc +1 more source
Pastos y ForrajesSe evaluó el efecto de un fertilizante químico compuesto (N-P2O5-K2O, 20-5-5), aplicado en dos formas (sólida y líquida), en algunos indicadores de la calidad del pasto kikuyo (Pennisetum clandestinum); el estudio se realizó en la hacienda La Montaña ...
Ana C Mejía-Taborda +2 more
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source