Results 101 to 110 of about 621,408 (312)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Integrative Modeling of Urinary Metabolomics and Metal Exposure Reveals Systemic Impacts of Electronic Waste in Exposed Populations

Metabolites
Background: Informal electronic waste (e-waste) recycling practices release a complex mixture of pollutants, particularly heavy metals, into the environment.
Fiona Hui, Zhiqiang Pang, Charles Viau, Gerd U. Balcke, Julius N. Fobil, Niladri Basu, Jianguo Xia   +6 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. [PDF]

, 2018
Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of ...
A Cleasby, A Dhar, A Kobayashi, A Moraru, A Shevchenko, A Uruno, AC Ruifrok, Arnab K. Chatterjee, BR Sabari, BT Weinert, CL Saw, Claudio Zambaldo, D Martinez Molina, DD Zhang, Emily N. Chin, FW Chaplen, Gihoon Lee, GP Sykiotis, GR Wagner, H Lin, Hwayoung Yun, Insha Ahmad, Jae Won Chang, John S. Coukos, JW Chang, Luke L. Lairson, M Ravichandran, MC Jaramillo, Michael J. Bollong, N Rabbani, N Rabbani, N Wakabayashi, Peter G. Schultz, Raymond E. Moellering, RE Moellering, RH Scannevin, S Nishimoto, S Tao, SC Lo, T Bücher, T Ogura, TB El-Abaseri, TO Khor, TW Lo, W Hur, W Hur, Y Mitsuishi, Z Zhang   +47 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Organizational and activational effects of estrogenic endocrine disrupting chemicals

Cadernos de Saúde Pública
Endocrine disruption is a hypothesis of common mode of action that may define a set of structurally varied chemicals, both natural and synthetic. Their common mode of action may suggest that they produce or contribute to similar toxic effects, although ...
Ellen K. Silbergeld, Jodi A. Flaws, Ken M. Brown   +2 more
doaj  

Humphrey Center News: Spring 1989 v. 4, no. 1 [PDF]

, 1989
Newsletter of the Hubert H.
Hubert H. Humphrey Cancer Research Center of Boston University, Ledani, Sarita   +1 more
core  

Synthesis of nine safrole derivatives and their antiproliferative activity towards human cancer cells [PDF]

, 2010
Indexación: ScieloSafrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure.
Carrasco Altamirano, Héctor, Cuellar Fritis, Mauricio, Espinoza Catalán, Luis, Madrid Villegas, Alejandro, Taborga Liber, Lautaro, Villena García, Joan   +5 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Endocrine disrupting chemicals: harmful substances and how to test them

Cadernos de Saúde Pública
This paper presents an analysis of the opinions of different groups from: scientists, international regulatory bodies, non-governmental organizations and industry; with an interest in the problem of identifying chemical substances with endocrine ...
Nicolás Olea-Serrano, Mariana F. Fernández-Cabrera, Rosa Pulgar-Encinas, Fátima Olea-Serrano   +3 more
doaj