Results 161 to 170 of about 4,446,617 (245)

Biophysical Sensing Tools in Drug Discovery: Integrating Kinetics, Thermodynamics, Cellular Target Engagement and Structure. [PDF]

Sensors (Basel)
Balıkçı E, Akıl C.
europepmc   +1 more source

Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self‐Sufficient Viral Restriction Factors

Angewandte Chemie International Edition, EarlyView.
CYB5R3 is identified as a putative electron‐transfer partner of viperin (RSAD2), explaining why ER localisation is required for antiviral activity. Its utilisation enabled the engineering of immune‐silent, catalytically self‐sufficient antiviral restriction factor enzymes (iCAREs) that produce an antiviral nucleoside triphosphate analogue (ANTA ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

Radiation damage in sub-Ångström resolution macromolecular crystallography: a low-dose study. [PDF]

Acta Crystallogr D Struct Biol
Bourenkov G, Paknia E, Flensburg C, Fogh R, Keller P, Vonrhein C, Bricogne G, Chari A.   +7 more
europepmc   +1 more source

Teaching chemical crystallography without a diffractometer [PDF]

Acta Crystallographica Section A Foundations and Advances, 2017
openaire   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Rh(iii)-catalyzed oxidative C-H annulation of 6-arylpyridazin-3(2<i>H</i>)-ones: direct access to diarylpyridazino[6,1-<i>a</i>]isoquinolin-5-ium-3-olates. [PDF]

RSC Adv
Ittamalla C, Mukundram NSS, Nagireddy J, Sridhar B, Reddy BVS.   +4 more
europepmc   +1 more source

¹H-¹H Interatomic Distances in Paracetamol-Based Structures Unveiled by Double-Quantum NMR and DFT Calculations. [PDF]

Molecules
Balodis M, Stevensson B, Majhi D, Nguyen TM, Hareendran C, Edén M.   +5 more
europepmc   +1 more source

Structural pharmacology of Chinese medicine: technological breakthroughs in decoding multi-target synergy and precision mechanisms. [PDF]

Adv Biotechnol (Singap)
Wang C, Li Y, Zhuo L, Xu S, Wang M, Liu Z.   +5 more
europepmc   +1 more source

Automated microbatch-under-oil phase diagrams to rationalize serial crystallography sample preparation. [PDF]

IUCrJ
Stubbs J, Tremlett CJ, Waitman A, Harmer NJ, Orville AM, Tews I, Kolek S, Shaw Stewart PD.   +7 more
europepmc   +1 more source